6scl

Cryo-EM Structure of Barley Yellow Dwarf Virus VLP

Loading... Status: waiting for Mol* initialization Structural highlights 6scl is a 3 chain structure with sequence from Barley yellow dwarf virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function O56812_9TOMB Publication Abstract from PubMed The Luteoviridae are pathogenic plant viruses responsible for significant crop losses worldwide. They infect a wide range of food crops, including cereals, legumes, cucurbits, sugar beet, sugarcane, and potato and, as such, are a major threat to global food security. Viral replication is strictly limited to the plant vasculature, and this phloem limitation, coupled with the need for aphid transmission of virus particles, has made it difficult to generate virus in the quantities needed for high-resolution structural studies. Here, we exploit recent advances in heterologous expression in plants to produce sufficient quantities of virus-like particles for structural studies. We have determined their structures to high resolution by cryoelectron microscopy, providing the molecular-level insight required to rationally interrogate luteovirid capsid formation and aphid transmission, thereby providing a platform for the development of preventive agrochemicals for this important family of plant viruses. Combining Transient Expression and Cryo-EM to Obtain High-Resolution Structures of Luteovirid Particles.,Byrne MJ, Steele JFC, Hesketh EL, Walden M, Thompson RF, Lomonossoff GP, Ranson NA Structure. 2019 Oct 8. pii: S0969-2126(19)30316-8. doi:, 10.1016/j.str.2019.09.010. PMID:31611039 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Virus coat proteins 3D structures

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