1i02: Difference between revisions

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==NMR STRUCTURE OF CTX A3 AT NEUTRAL PH (20 STRUCTURES)==
==NMR STRUCTURE OF CTX A3 AT NEUTRAL PH (20 STRUCTURES)==
<StructureSection load='1i02' size='340' side='right'caption='[[1i02]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1i02' size='340' side='right'caption='[[1i02]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1i02]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I02 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1i02]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I02 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cb9|1cb9]], [[1cdt|1cdt]], [[2cdx|2cdx]], [[2crt|2crt]], [[1kxi|1kxi]], [[1tgx|1tgx]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i02 OCA], [http://pdbe.org/1i02 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1i02 RCSB], [http://www.ebi.ac.uk/pdbsum/1i02 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1i02 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i02 OCA], [https://pdbe.org/1i02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i02 RCSB], [https://www.ebi.ac.uk/pdbsum/1i02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i02 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/3SA3_NAJAT 3SA3_NAJAT]] Basic protein that binds to cell membrane and depolarizes cardiomyocytes. This cytotoxin also possesses lytic activity on many other cells, including red blood cells (PubMed:8182052). Interaction with sulfatides in the cell membrane induces pore formation and cell internalization. Cytotoxicity is due to pore formation, and to another mechanism independent of membrane-damaging activity. When internalized, it targets the mitochondrial membrane and induces mitochondrial swelling and fragmentation. It inhibits protein kinases C. It binds to the integrin alpha-V/beta-3 (ITGAV/ITGB3) with a moderate affinity (PubMed:16407244). It also binds with high affinity to heparin (PubMed:17685633).<ref>PMID:15922335</ref> <ref>PMID:16263708</ref> <ref>PMID:16407244</ref> <ref>PMID:17714752</ref> <ref>PMID:8182052</ref> <ref>PMID:8448165</ref> <ref>PMID:9245415</ref>
[https://www.uniprot.org/uniprot/3SA3_NAJAT 3SA3_NAJAT] Basic protein that binds to cell membrane and depolarizes cardiomyocytes. This cytotoxin also possesses lytic activity on many other cells, including red blood cells (PubMed:8182052). Interaction with sulfatides in the cell membrane induces pore formation and cell internalization. Cytotoxicity is due to pore formation, and to another mechanism independent of membrane-damaging activity. When internalized, it targets the mitochondrial membrane and induces mitochondrial swelling and fragmentation. It inhibits protein kinases C. It binds to the integrin alpha-V/beta-3 (ITGAV/ITGB3) with a moderate affinity (PubMed:16407244). It also binds with high affinity to heparin (PubMed:17685633).<ref>PMID:15922335</ref> <ref>PMID:16263708</ref> <ref>PMID:16407244</ref> <ref>PMID:17714752</ref> <ref>PMID:8182052</ref> <ref>PMID:8448165</ref> <ref>PMID:9245415</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i0/1i02_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i0/1i02_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Naja atra]]
[[Category: Naja atra]]
[[Category: Harold, J]]
[[Category: Harold J]]
[[Category: Sue, S C]]
[[Category: Sue S-C]]
[[Category: Wu, W g]]
[[Category: Wu W-g]]
[[Category: Bound water]]
[[Category: Cardiotoxin]]
[[Category: Ctx]]
[[Category: Cytotoxin]]
[[Category: Gag binding protein]]
[[Category: Hemolysis]]
[[Category: Membrane binding protein]]
[[Category: Three-finger type]]
[[Category: Toxin]]
Retrieved from "https://proteopedia.org/1i02"