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==Cryo-EM structure of the mitochondrial TOM complex from yeast (tetramer)==
==Cryo-EM structure of the mitochondrial TOM complex from yeast (tetramer)==
<StructureSection load='6ucv' size='340' side='right'caption='[[6ucv]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
<SX load='6ucv' size='340' side='right' viewer='molstar' caption='[[6ucv]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6ucv]] is a 20 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UCV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UCV FirstGlance]. <br>
<table><tr><td colspan='2'>[[6ucv]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UCV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UCV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MC3:1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE'>MC3</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ucv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ucv OCA], [http://pdbe.org/6ucv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ucv RCSB], [http://www.ebi.ac.uk/pdbsum/6ucv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ucv ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MC3:1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE'>MC3</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ucv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ucv OCA], [https://pdbe.org/6ucv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ucv RCSB], [https://www.ebi.ac.uk/pdbsum/6ucv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ucv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TOM6_YEAST TOM6_YEAST]] Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. TOM6 is involved in assembly and stability of the TOM complex.<ref>PMID:11276259</ref>  [[http://www.uniprot.org/uniprot/TOM40_YEAST TOM40_YEAST]] Channel-forming protein essential for import of protein precursors into mitochondria.<ref>PMID:10427088</ref> [[http://www.uniprot.org/uniprot/TOM5_YEAST TOM5_YEAST]] Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. TOM5 is involved in insertion of preproteins into the TOM40 translocation pore.<ref>PMID:9217162</ref>  [[http://www.uniprot.org/uniprot/TOM22_YEAST TOM22_YEAST]] Central component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM20 and TOM70 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore. Docks TOM20 and TOM70 for interaction with the general TOM40 import pore (GIP) complex. May regulate the TOM machinery organization, stability and channel gating.<ref>PMID:10519552</ref> <ref>PMID:11276259</ref> <ref>PMID:7760834</ref>  [[http://www.uniprot.org/uniprot/TOM7_YEAST TOM7_YEAST]] Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. TOM7 is involved in assembly and stability of the TOM complex.<ref>PMID:11276259</ref> 
[https://www.uniprot.org/uniprot/TOM40_YEAST TOM40_YEAST] Channel-forming protein essential for import of protein precursors into mitochondria.<ref>PMID:10427088</ref>  
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Park, E]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Tucker, K]]
[[Category: Park E]]
[[Category: Membrane protein]]
[[Category: Tucker K]]
[[Category: Mitochondrial outer membrane]]
[[Category: Mitochondrial protein import]]
[[Category: Protein translocation]]
[[Category: Translocase]]

Latest revision as of 09:29, 20 March 2024

Cryo-EM structure of the mitochondrial TOM complex from yeast (tetramer)

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