6e5f: Difference between revisions

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<StructureSection load='6e5f' size='340' side='right'caption='[[6e5f]], [[Resolution|resolution]] 1.37&Aring;' scene=''>
<StructureSection load='6e5f' size='340' side='right'caption='[[6e5f]], [[Resolution|resolution]] 1.37&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6e5f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E5F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E5F FirstGlance]. <br>
<table><tr><td colspan='2'>[[6e5f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E5F FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=L6T:alpha-D-glucopyranosyl+6-O-dodecyl-alpha-D-glucopyranoside'>L6T</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.37&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lpqN, Rv0583c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L6T:alpha-D-glucopyranosyl+6-O-dodecyl-alpha-D-glucopyranoside'>L6T</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e5f OCA], [http://pdbe.org/6e5f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e5f RCSB], [http://www.ebi.ac.uk/pdbsum/6e5f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e5f ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e5f OCA], [https://pdbe.org/6e5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e5f RCSB], [https://www.ebi.ac.uk/pdbsum/6e5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e5f ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LPQN_MYCTU LPQN_MYCTU] Involved in cell envelope biogenesis. May act as a membrane fusion protein, connecting MmpL transporters with periplasmic proteins, and play a role in cell envelope lipid changes during biofilm maturation.<ref>PMID:31471317</ref>  Is also a virulence factor required for intracellular survival (PubMed:30118682). Associates with CBL, a host ubiquitin ligase, and probably blocks the normal functions of CBL and disturbs CBL-mediated antibacterial activity (PubMed:30118682). Interaction counteracts antibacterial defense but causes a reciprocal enhancement of antiviral defense (PubMed:30118676, PubMed:30118682).<ref>PMID:30118682</ref> <ref>PMID:30118676</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Myctu]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Rajavel, M]]
[[Category: Rajavel M]]
[[Category: Su, C C]]
[[Category: Su CC]]
[[Category: Yu, E W]]
[[Category: Yu EW]]
[[Category: Lipid binding protein]]
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