Neuraminidase 3D structures: Difference between revisions

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New page: ==3D structures of Neuraminidase== Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *'''Influenza virus neuraminidas...
 
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{{#tree:id=OrganizedByTopic|openlevels=0|


*'''Influenza virus neuraminidase'''
*Neuraminidase


**[[3nss]], [[3k36]], [[3beq]], [[3cye]], [[2cml]], [[2b8h]], [[2ht5]], [[1v0z]], [[1nn2]], [[4hzv]], [[4fvk]], [[4gez]] – IvNANA residues 82-469 – Influenza virus<br />
**[[1snt]], [[1so7]] – hNeu2 - human<br />
**[[2f24]], [[2f26]], [[2f28]] – hNeu2 (mutant) <br />
**[[8du5]] – mNeu1 - mouse<br />
**[[2vvz]], [[2w20]], [[2ya4]] – SpNANA catalytic domain – ''Streptococcus pneumoniae''<br />
**[[3h71]] - SpNANA catalytic domain precursor<br />
**[[4zxk]] - SpNANA carbohydrate-binding domain<br />
**[[4yw4]], [[4yz4]] – SpNANC<br />
**[[2xcy]], [[2xzi]], [[2xzj]], [[2xzk]] – NANA – ''Aspergillus fumigatus''<br />
**[[2w68]] – VcNANA sialic acid binding domain – ''Vibrio cholerae''<br />
**[[1kit]], [[1w0o]] – VcNANA<br />
**[[1eur]] - MvNANA residues 43-407 – ''Micromonospora viridifaciens''<br />
**[[1euu]] - MvNANA residues 47-647 <br />
**[[1w8n]], [[1w8o]], [[1wcq]], [[2hu0]], [[2hu4]] – MvNANA residues 47-647 (mutant) <br />
**[[3sil]], [[6trg]], [[7af2]]– StNANA (mutant) – ''Salmonella typhimurium''<br />
**[[4bbw]], [[5muk]] – BtNAN – ''Bacterioides thetaiotaomicro''n<br />
**[[5tsp]] - NANI + CHES – ''Clostridium perfringens''<br />
**[[6mrx]] - baNANA - bacterium<br />
 
*Binary complexes
 
**[[2f0z]], [[2f10]], [[2f11]], [[2f12]], [[2f13]] – hNeu2 + inhibitor <br />
**[[2f25]], [[2f27]], [[2f29]], [[4nc5]], [[4ncs]] - hNeu2 (mutant) + sialic acid analog<br />
**[[1vcu]] - hNeu2 + sialic acid analog<br />
**[[3h72]] - SpNANA catalytic domain precursor + sialic derivative<br />
**[[3h73]] - SpNANA catalytic domain precursor + sialic acid analog<br />
**[[2ya5]] - SpNANA catalytic domain + sialic acid<br />
**[[2ya7]], [[2ya8]], [[5f9t]], [[5kky]] - SpNANA catalytic domain + inhibitor<br />
**[[2ya6]]- SpNANA catalytic domain + sialic acid analog<br />
**[[4yw1]], [[4wy2]], [[4wy3]], [[4yz2]] – SpNANC + inhibitor<br />
**[[4yw1]] – SpNANC residues 83-740 + sialic acid + neuraminic acid derivative <br />
**[[4yw5]], [[4yz3]] – SpNANC + drug<br />
**[[6eks]], [[6eku]] – VcNANC + drug<br />
**[[1w0p]] – VcNANA + sialic derivative<br />
**[[1eus]] - MvNANA residues 43-407 + neuraminic acid derivative<br />
**[[2bzd]] - MvNANA residues 47-647 (mutant) + galactose<br />
**[[1eut]] - MvNANA residues 47-647 + galactose<br />
**[[2ber]] - MvNANA residues 47-647 (mutant) + sialic derivative<br />
**[[1dil]], [[1dim]] – StNANA + inhibitor<br />
**[[2sil]], [[2sim]], [[7aey]] - StNANA + neuraminic acid derivative<br />
**[[6tvi]] - StNANA (mutant) + neuraminic acid derivative<br />
**[[5mul]] – BtNAN + glucuronic acid<br />
**[[6myv]] - baNANA + neuraminic acid derivative <br />
 
*Influenza virus neuraminidase
 
**[[1nn2]], [[1v0z]], [[2b8h]], [[2cml]], [[2ht5]], [[3beq]], [[3cye]], [[3k36]], [[3nss]], [[4hzv]], [[4fvk]], [[4gez]], [[9gqt]], [[9gqx]] – IvNANA residues 82-469 – Influenza virus<br />
**[[4fvk]], [[4gez]] - IvNANA residues 76-442<br />
**[[4fvk]], [[4gez]] - IvNANA residues 76-442<br />
**[[3k38]], [[4hzy]] – IvNANA (mutant) <br />
**[[3k38]], [[4hzy]] – IvNANA (mutant) <br />
**[[4b7m]], [[6d96]] - IvNAN H1n1<br />
**[[4b7m]], [[6d96]], [[7s0i]] - IvNAN H1n1<br />
**[[6n4d]] – IvNAN H3n2<br />
**[[7u2q]], [[7u2t]] - IvNAN – Cryo EM<br />
**[[4cpl]], [[4cpn]], [[4cpo]] - IvNAN <br />
**[[6n4d]], [[7u4e]], [[7u4f]], [[7u4g]], [[9mqw]] – IvNAN H3n2<br />
**[[9cyg]], [[9ijv]] – IvNAN H3n2 – Cryo EM<br />
**[[4qn4]] – IvNAN H3n6<br />
**[[4qn4]] – IvNAN H3n6<br />
**[[4wa3]] – IvNAN H3n8<br />
**[[4wa3]] – IvNAN H3n8<br />
**[[5hug]], [[2ht5]], [[2htv]], [[2hty]] – IvNAN H5n1<br />
**[[2ht5]], [[2htv]], [[2hty]], [[5hug]] – IvNAN H5n1<br />
**[[9l44]] – IvNAN H5n1 – Cryo EM<br />
**[[5huk]] – IvNAN H5n2<br />
**[[5huk]] – IvNAN H5n2<br />
**[[5hun]], [[5hum]] – IvNAN H5n6<br />
**[[5hum]], [[5hun]] – IvNAN H5n6<br />
**[[5l14]], [[3nn9]], [[4nn9]], [[5nn9]], [[6nn9]], [[4mwj]], [[4mwl]] – IvNAN H7n9<br />
**[[3nn9]], [[4mwj]], [[4mwl]], [[4nn9]], [[5l14]], [[5nn9]], [[6nn9]] – IvNAN H7n9<br />
**[[6pzd]] – IvNAN H7n9 (mutant)<br />
**[[4qn3]] – IvNAN H10n7<br />
**[[4qn3]] – IvNAN H10n7<br />
**[[7nn9]], [[6mcx]] - IvNAN H11n9 Tern<br />
**[[6mcx]], [[7nn9]] - IvNAN H11n9 Tern<br />
**[[3sal]] - IvNAN H12n5 residues 82-469<br />
**[[3sal]] - IvNAN H12n5 residues 82-469<br />
**[[4gdi]], [[4gdj]] - IvNAN H17n10<br />
**[[4gdi]], [[4gdj]] - IvNAN H17n10<br />
**[[4mc7]] – IvNAN H18n11<br />
**[[4mc7]] – IvNAN H18n11<br />
**[[2hty]] - IvNAN N1 residues 82-469<br />
**[[2hty]], [[9gqq]] - IvNAN N1 residues 82-469<br />
**[[9ewq]] - IvNAN N1 residues 82-469 – Cryo EM<br />
**[[4gzo]], [[4k1h]], [[4k1i]], [[4k1k]] - IvNAN N2 residues 77-469<br />
**[[4gzo]], [[4k1h]], [[4k1i]], [[4k1k]] - IvNAN N2 residues 77-469<br />
**[[4gzs]], [[4k1j]] - IvNAN N2 residues 77-469 (mutant)<br />
**[[4gzs]], [[4k1j]] - IvNAN N2 residues 77-469 (mutant)<br />
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**[[6hgb]] – IvNAN N6<br />
**[[6hgb]] – IvNAN N6<br />
**[[2ht5]] – IvNAN N8 residues 82-469<br />
**[[2ht5]] – IvNAN N8 residues 82-469<br />
**[[6hfc]], [[6d3b]] – IvNAN N9<br />
**[[7nn9]] - IvNAN N9 Tern <br />
**[[2qwa]] - IvNAN N9 Tern (mutant)<br />
**[[2qwa]] - IvNAN N9 Tern (mutant)<br />
**[[6crd]] - IvNAN N9 Tern/tetrabrachion <br />
**[[7cm1]], [[7fgb]], [[7fgc]], [[7fgd]], [[7fge]] - IvNAN - toad<br />
**[[7xvr]], [[7xvu]], [[7xvv]], [[7xvw]] - IvNAN - eel<br />


*Binary complexes of Influenza virus neuraminidase
*Binary complexes of Influenza virus neuraminidase


**[[3o9j]], [[3o9k]], [[2c4a]], [[2c4l]], [[1w1x]], [[1w20]], [[1w21]], [[1nsb]], [[1nsc]], [[1nsd]] – IvNANA + sialic derivative<br />  
**[[1nsb]], [[1nsc]], [[1nsd]], [[1w1x]], [[1w20]], [[1w21]], [[2c4a]], [[2c4l]], [[3o9j]], [[3o9k]] – IvNANA + sialic derivative<br />  
**[[3k37]], [[3b7e]], [[1vcj]], [[1l7f]], [[1f8c]], [[1f8d]], [[1f8e]], [[1a4g]], [[1a4q]], [[1b9t]], [[1b9v]], [[1b9s]], [[1inf]], [[1ing]], [[1inh]], [[1ivb]], [[1ivc]], [[1ivd]], [[1ive]], [[1ivf]], [[1ivg]], [[4d8s]], [[4ks1]], [[4ks2]], [[4ks3]], [[4ks4]], [[4ks5]], [[4m3m]], [[4mju]], [[4mjv]] – IvNANA + inhibitor<br />
**[[1a4g]], [[1a4q]], [[1b9s]], [[1b9t]], [[1b9v]], [[1f8c]], [[1f8d]], [[1f8e]], [[1inf]], [[1ing]], [[1inh]], [[1ivb]], [[1ivc]], [[1ivd]], [[1ive]], [[1ivf]], [[1ivg]], [[1l7f]], [[1vcj]], [[3b7e]], [[3k37]], [[4d8s]], [[4ks1]], [[4ks2]], [[4ks3]], [[4ks4]], [[4ks5]], [[4m3m]], [[4mju]], [[4mjv]] – IvNANA + inhibitor<br />
**[[3k39]], [[3k3a]], [[3ckz]], [[3cl0]], [[3cl2]], [[1l7g]], [[1l7h]] - IvNANA (mutant) + inhibitor<br />
**[[1l7g]], [[1l7h]], [[3ckz]], [[3cl0]], [[3cl2]], [[3k39]], [[3k3a]] - IvNANA (mutant) + inhibitor<br />
**[[1f8b]], [[1inv]], [[1inw]], [[1inx]], [[1iny]], [[4gb1]] – IvNANA + sialic acid analog<br />
**[[1f8b]], [[1inv]], [[1inw]], [[1inx]], [[1iny]], [[4gb1]] – IvNANA + sialic acid analog<br />
**[[3ti3]], [[3ti4]], [[3ti5]], [[3ti6]], [[6g02]], [[6g01]] - IvNAN H1n1 + inhibitor<br />
**[[3ti3]], [[3ti4]], [[3ti5]], [[3ti6]], [[6g01]], [[6g02]] – IvNAN H1n1 + inhibitor<br />
**[[4qnp]], [[6q23]] - IvNAN H1n1 + antibody<br />
**[[4qnp]], [[6lxi]], [[6lxk]], [[6q23]] - IvNAN H1n1 + antibody<br />
**[[8e6j]], [[8e6k]], [[8ez8]], [[8g30]], [[8g3m]], [[8g3n]], [[8g3o]], [[8g3p]], [[8g3q]], [[8g3r]], [[8g3v]], [[8g3z]], [[8g40]], [[8u1c]], [[8u1q]], [[8u1s]], [[8yvl]], [[8zr4]], [[9cye]], [[9cyh]], [[9dpc]], [[9eje]], [[9ejf]], [[9kod]], [[9md2]], [[9md3]], [[9md5]], [[9md6]], [[9o4n]], [[9o4o]], [[9o4p]], [[9o4q]], [[9o9v]] - IvNAN H1n1 + antibody – Cryo EM<br />
**[[9fm2]] - IvNAN H1n1 + Vhh – Cryo EM<br />
**[[3tia]], [[3tib]], [[3tic]] – IvNAN H2n2 + inhibitor<br />
**[[3tia]], [[3tib]], [[3tic]] – IvNAN H2n2 + inhibitor<br />
**[[6q20]] - IvNAN H2n2 + antibody<br />
**[[6q20]] - IvNAN H2n2 + antibody<br />
**[[6n6b]] - IvNAN H3n2 + antibody<br />
**[[6n6b]], [[9mqv]] - IvNAN H3n2 + antibody<br />
**[[2bat]], [[4gzw]], [[4gzx]], [[4gzq]] – IvNAN H3n2 + sialic acid<br />
**[[8ez3]], [[8ez7]], [[8gat]], [[8gau]], [[8gav]], [[8yvm]], [[8yvn]], [[8zyx]], [[9cyf]], [[9cyi]], [[9cyj]], [[9osr]] - IvNAN H3n2 + antibody – Cryo EM<br />
**[[2bat]], [[4gzq]], [[4gzw]], [[4gzx]], [[8dwb]] – IvNAN H3n2 + sialic acid<br />
**[[2ht7]], [[2ht8]], [[2htq]], [[2htu]] – IvNAN H5n1 + inhibitor<br />
**[[2ht7]], [[2ht8]], [[2htq]], [[2htu]] – IvNAN H5n1 + inhibitor<br />
**[[2htr]], [[2htw]] – IvNAN H5n1 + sialic acid analog<br /
**[[2htr]], [[2htw]] – IvNAN H5n1 + sialic acid analog<br />
**[[8z4e]] - IvNAN H5n6 + scFv – Cryo EM<br />
**[[5l18]] - IvNAN H7n9 + sialic acid<br />
**[[5l18]] - IvNAN H7n9 + sialic acid<br />
**[[6q1z]] - IvNAN H7n9 + antibody<br />
**[[6lxj]], [[6q1z]], [[6pzf]], [[6pzw]], [[6pzy]], [[6pzz]] - IvNAN H7n9 + antibody<br />
**[[1nna]], [[1nnb]], [[5w2y]], [[5w2w]], [[5w2u]], [[5w26]] - IvNAN H11n9 + neuraminic acid derivative<br />
**[[6u02]] - IvNAN H7n9 + antibody – Cryo EM<br />
**[[6pze]] - IvNAN H7n9 (mutant) + antibody<br />
**[[6v4n]], [[6v4o]] - IvNAN + antibody – Cryo EM<br />
**[[8yvk]] - IvNAN H10n4 + antibody – Cryo EM<br />
**[[9eit]] - IvNAN H10n5 + antibody – Cryo EM<br />
**[[1nna]], [[1nnb]], [[5w26]], [[5w2u]], [[5w2w]], [[5w2y]] - IvNAN H11n9 + neuraminic acid derivative<br />
**[[4dgr]] - IvNAN H11n9 + benzoic acid derivative<br />
**[[4dgr]] - IvNAN H11n9 + benzoic acid derivative<br />
**[[4weg]] - IvNAN H11n9 + sialic acid derivative <br />
**[[4weg]] - IvNAN H11n9 + sialic acid derivative <br />
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**[[1mwe]] - IvNAN N9 Tern + sialic acid<br />
**[[1mwe]] - IvNAN N9 Tern + sialic acid<br />
**[[2qwf]], [[2qwg]], [[2qwh]], [[2qwi]], [[2qwj]], [[2qwk]] - IvNAN N9 Tern (mutant) + inhibitor<br />
**[[2qwf]], [[2qwg]], [[2qwh]], [[2qwi]], [[2qwj]], [[2qwk]] - IvNAN N9 Tern (mutant) + inhibitor<br />
**[[1nma]], [[1nmb]], [[1a14]], [[1nca]], [[1ncb]], [[1ncc]], [[1ncd]], [[2aep]], [[2aeq]], [[1nmc]] - IvNAN N9 Tern + antibody – mouse<br />
**[[1a14]], [[1nca]], [[1ncb]], [[1ncc]], [[1ncd]], [[1nma]], [[1nmb]], [[1nmc]], [[2aep]], [[2aeq]] - mIvNAN N9 Tern + antibody <br />


*Binary complexes of Influenza virus neuraminidase with drugs
*Binary complexes of Influenza virus neuraminidase with drug


**[[4b7j]], [[4b7n]], [[4b7q]], [[4b7r]], [[5nzn]], [[6hp0]] - IvNAN H1n1 + drug<br />
**[[4b7j]], [[4b7n]], [[4b7q]], [[4b7r]], [[4cpm]], [[4cpy]], [[4cpz]], [[5nzn]], [[6hp0]], [[9hlg]], [[9hlh]], [[9hli]] - IvNAN H1n1 + drug<br />
**[[5nzf]], [[5nze]], [[5nz4]], [[5nwe]] - IvNAN H1n1 (mutant) + drug<br />
**[[5nwe]], [[5nz4]], [[5nze]], [[5nzf]] - IvNAN H1n1 (mutant) + drug<br />
**[[4gzp]], [[4gzt]], [[6br6]], [[6br5]] - IvNAN H3n2 + drug<br />
**[[4gzp]], [[4gzt]], [[6br5]], [[6br6]] - IvNAN H3n2 + drug<br />
**[[4qn6]] - IvNAN H3n6 + drug<br />
**[[4qn6]] - IvNAN H3n6 + drug<br />
**[[4wa5]], [[4wa4]] - IvNAN H3n8 + drug<br />
**[[4wa4]], [[4wa5]] - IvNAN H3n8 + drug<br />
**[[5l15]], [[5l17]], [[5jyy]], [[4mwq]], [[4mwr]], [[4mwu]], [[4mwv]], [[4mww]], [[4mwx]], [[4mwy]], [[4mx0]]   - IvNAN H7n9 + drug<br />
**[[4mwq]], [[4mwr]], [[4mwu]], [[4mwv]], [[4mww]], [[4mwx]], [[4mwy]], [[4mx0]], [[5jyy]], [[5l15]], [[5l17]] - IvNAN H7n9 + drug<br />
**[[4mwq]], [[4mwr]], [[4mwu]], [[4mwv]], [[4mww]], [[4mwx]], [[4mwy]], [[4mx0]]  - IvNAN H7n9 + flu drug<br />
**[[4mwq]], [[4mwr]], [[4mwu]], [[4mwv]], [[4mww]], [[4mwx]], [[4mwy]], [[4mx0]]  - IvNAN H7n9 + flu drug<br />
**[[4qn7]]- IvNAN H10n7 + drug<br />
**[[4qn7]]- IvNAN H10n7 + drug<br />
**[[3san]], [[3ti8]] - IvNAN H12N5 + flu drug<br />
**[[3san]], [[3ti8]], [[7e6q]] - IvNAN H12N5 + flu drug<br />
**[[4hzw]], [[4hzx]] - IvNAN N3 + flu drug<br />
**[[4hzw]], [[4hzx]] - IvNAN N3 + flu drug<br />
**[[4hzz]], [[4i00]] - IvNAN N3 (mutant) + flu drug<br />
**[[4hzz]], [[4i00]] - IvNAN N3 (mutant) + flu drug<br />
**[[3san]], [[3ti8]] - IvNAN N5 + flu drug<br />
**[[6hg5]] - IvNAN N6 + flu drug<br />
**[[6hg5]] - IvNAN N6 + flu drug<br />
**[[6hfy]] - IvNAN N6 + DANA<br />
**[[6hfy]] - IvNAN N6 + neuraminic acid derivative <br />
**[[6heb]], [[6hcx]] - IvNAN N9 + flu drug<br />
**[[6heb]], [[6hcx]] - IvNAN N9 + flu drug<br />
**[[6hg0]] - IvNAN N9 Tern + NANA<br />
**[[6hg0]] - IvNAN N9 Tern + NANA<br />


*'''Endo-neuraminidase'''
*Endo-neuraminidase


**[[3gvf]], [[3gvk]], [[3gvj]] – ENANA (mutant) residues 246-910 – Enterobacteria phage K1F<br />
**[[3gvf]], [[3gvj]] , [[3gvk]] – ENANA (mutant) residues 246-910 – ''Enterobacteria'' phage K1F
**[[3gvl]], [[3ju4]] – ENANA residues 246-910<br />
**[[3gvl]], [[3ju4]] – ENANA residues 246-910
**[[3gw6]] – ENANA residues 790-1064<br />
**[[3gw6]] – ENANA residues 790-1064


*'''Pseudaminidase'''
*Pseudaminidase


**[[2w38]], [[3h6j]] – PNANA – ''Pseudomonas aeruginosa''
**[[2w38]], [[3h6j]] – PNANA – ''Pseudomonas aeruginosa''


*'''Trans-sialidase'''
*Trans-sialidase


**[[2sli]], [[1sli]], [[3sli]] – lTS + inhibitor – leech<br />
**[[1sli]], [[2sli]], [[3sli]] – lTS + inhibitor – leech
**[[1mr5]], [[1ms3]], [[1ms4]] - TcTS (mutant) – ''Trypanosoma cruzi''<br />
**[[1mr5]], [[1ms3]], [[1ms4]] - TcTS (mutant) – ''Trypanosoma cruzi''<br />
**[[1ms0]] - TcTS (mutant) + DANA + lactose<br />
**[[1ms0]] - TcTS (mutant) + neuraminic acid derivative + lactose<br />
**[[1ms1]], [[1ms8]] - TcTS (mutant) + DANA <br />
**[[1ms1]], [[1ms8]] - TcTS (mutant) + neuraminic acid derivative <br />
**[[3b69]] - TcTS (mutant) + NANA derivative<br />
**[[3b69]] - TcTS (mutant) + NANA derivative<br />
**[[1ms5]] - TcTS (mutant) + Na-S-Gal<br />
**[[1ms5]] - TcTS (mutant) + Na-S-Gal<br />
Line 101: Line 167:
**[[2ah2]] - TcTS (mutant) + difluorosialic acid<br />
**[[2ah2]] - TcTS (mutant) + difluorosialic acid<br />


*Neuraminidase B or sialidase B
**[[2vw0]], [[2vw1]], [[2vw2]] – SpNANB<br />
**[[4xhb]], [[4xik]], [[4xio]], [[4xjz]], [[4xmi]] - SpNANB (mutant) <br />
**[[4foq]], [[4fov]], [[4fow]], [[4foy]], [[4fp2]], [[4fp3]], [[4fpc]], [[4fpe]], [[4fpf]], [[4fpg]], [[4fph]], [[4fpj]], [[4fpk]], [[4fpl]], [[4fpo]], [[4fpy]], [[4fq4]], [[4xe9]], [[4xhx]], [[4xil]], [[4xj9]], [[4xja]], [[4xju]], [[4xjw]], [[4xma]] - SpNANB (mutant) + inhibitor<br />
**[[4xog]] - SpNANB (mutant) + neuraminic acid derivative + inhibitor<br />
**[[2jkb]], [[4xj8]] - SpNANB residues 30-697 + sialic acid analog<br />
**[[4c1w]] - SpNANB residues 52-236 + sialic acid derivative<br />
**[[4xyx]] – SpNANB + drug<br />
**[[4yw2]] – SpNANB residues 83-740 + sialic acid<br />
}}
}}


[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 08:45, 24 March 2026

3D structures of Neuraminidase

Updated on 24-March-2026

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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