6uuz: Difference between revisions
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==Structure of ACLY in the presence of citrate and CoA== | |||
<SX load='6uuz' size='340' side='right' viewer='molstar' caption='[[6uuz]], [[Resolution|resolution]] 3.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6uuz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UUZ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6uuz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uuz OCA], [https://pdbe.org/6uuz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6uuz RCSB], [https://www.ebi.ac.uk/pdbsum/6uuz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6uuz ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ACLY_HUMAN ACLY_HUMAN] ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.<ref>PMID:23932781</ref> | |||
==See Also== | |||
*[[ATP-citrate synthase 3D structures|ATP-citrate synthase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Xuepeng | __TOC__ | ||
</SX> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Ronen M]] | |||
[[Category: Xuepeng W]] | |||
Latest revision as of 14:33, 6 March 2024
Structure of ACLY in the presence of citrate and CoA
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