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| ==Solution structure of the PPIase domain of TbPar42== | | ==Solution structure of the PPIase domain of TbPar42== |
| <StructureSection load='2n87' size='340' side='right'caption='[[2n87]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | | <StructureSection load='2n87' size='340' side='right'caption='[[2n87]]' scene=''> |
| == Structural highlights == | | == Structural highlights == |
| <table><tr><td colspan='2'>[[2n87]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Tryb2 Tryb2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N87 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N87 FirstGlance]. <br> | | <table><tr><td colspan='2'>This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2mnt 2mnt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N87 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N87 FirstGlance]. <br> |
| </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2n84|2n84]]</td></tr> | | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n87 OCA], [https://pdbe.org/2n87 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n87 RCSB], [https://www.ebi.ac.uk/pdbsum/2n87 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n87 ProSAT]</span></td></tr> |
| <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tb927.7.2480 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=185431 TRYB2])</td></tr>
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| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n87 OCA], [http://pdbe.org/2n87 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n87 RCSB], [http://www.ebi.ac.uk/pdbsum/2n87 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n87 ProSAT]</span></td></tr> | |
| </table> | | </table> |
| <div style="background-color:#fffaf0;">
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| == Publication Abstract from PubMed ==
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| Trypanosoma brucei is a unicellular eukaryotic parasite, which causes the African sleeping sickness in humans. The recently discovered trypanosomal protein Parvulin 42 (TbPar42) plays a key role in parasite cell proliferation. Homologues of this two-domain protein are exclusively found in protozoa species. TbPar42 exhibits an N-terminal forkhead associated (FHA)-domain and a peptidyl-prolyl-cis/trans-isomerase (PPIase) domain, both connected by a linker. Using NMR and X-ray analysis as well as activity assays, we report on the structures of the single domains of TbPar42, discuss their intra-molecular interplay, and give some initial hints as to potential cellular functions of the protein.
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| Structural Analysis of the 42 kDa Parvulin of Trypanosoma brucei.,Rehic E, Hoenig D, Kamba BE, Goehring A, Hofmann E, Gasper R, Matena A, Bayer P Biomolecules. 2019 Mar 7;9(3). pii: biom9030093. doi: 10.3390/biom9030093. PMID:30866577<ref>PMID:30866577</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| <div class="pdbe-citations 2n87" style="background-color:#fffaf0;"></div>
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| == References ==
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| <references/>
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| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |
| [[Category: Large Structures]] | | [[Category: Large Structures]] |
| [[Category: Tryb2]]
| | [[Category: Bayer P]] |
| [[Category: Bayer, P]] | | [[Category: Rehic E]] |
| [[Category: Rehic, E]] | |
| [[Category: Isomerase]]
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| [[Category: Parvulin]]
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| [[Category: Ppiase domain]]
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