5vsl: Difference between revisions

<table><tr><td colspan='2'>[[5vsl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VSL FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.972&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vsl OCA], [https://pdbe.org/5vsl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vsl RCSB], [https://www.ebi.ac.uk/pdbsum/5vsl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vsl ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/RSAD2_MOUSE RSAD2_MOUSE] Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of viruses, including west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus and vesicular stomatitis virus (VSV). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, through binding and inhibition of the enzyme farnesyl diphosphate synthase (FPPS), which is essential for the biosynthesis of isoprenoid-derived lipids. Promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating Lys-63'-linked ubiquitination of IRAK1. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins.<ref>PMID:17686841</ref> <ref>PMID:19047684</ref> <ref>PMID:21435586</ref> <ref>PMID:21880757</ref>  

[[Category: Mus musculus]]

[[Category: Cresswell P]]

[[Category: Ealick SE]]

[[Category: Fenwick MK]]

[[Category: Li Y]]

[[Category: Modis Y]]