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| <StructureSection load='6jo7' size='340' side='right'caption='[[6jo7]], [[Resolution|resolution]] 2.40Å' scene=''> | | <StructureSection load='6jo7' size='340' side='right'caption='[[6jo7]], [[Resolution|resolution]] 2.40Å' scene=''> |
| == Structural highlights == | | == Structural highlights == |
| <table><tr><td colspan='2'>[[6jo7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JO7 FirstGlance]. <br> | | <table><tr><td colspan='2'>[[6jo7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JO7 FirstGlance]. <br> |
| </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Mxra8, Asp3, Dicam ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> | | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> |
| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jo7 OCA], [http://pdbe.org/6jo7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jo7 RCSB], [http://www.ebi.ac.uk/pdbsum/6jo7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jo7 ProSAT]</span></td></tr> | | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jo7 OCA], [https://pdbe.org/6jo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jo7 RCSB], [https://www.ebi.ac.uk/pdbsum/6jo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jo7 ProSAT]</span></td></tr> |
| </table> | | </table> |
| == Function ==
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| [[http://www.uniprot.org/uniprot/MXRA8_MOUSE MXRA8_MOUSE]] Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed:18366072, PubMed:22492581, PubMed:29702220). Mediates heterophilic cell-cell interactions in vitro (PubMed:18366072). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (PubMed:22492581). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (PubMed:29702220). Stimulates formation of primary cilia in chondrocytes (PubMed:29702220). Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway (PubMed:29702220). Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis (By similarity). Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells (By similarity). Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK (By similarity). May play a role in the maturation and maintenance of the blood-brain barrier (PubMed:14603461).[UniProtKB:Q9BRK3]<ref>PMID:14603461</ref> <ref>PMID:18366072</ref> <ref>PMID:22492581</ref> <ref>PMID:29702220</ref>
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| <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| </StructureSection> | | </StructureSection> |
| [[Category: Large Structures]] | | [[Category: Large Structures]] |
| [[Category: Lk3 transgenic mice]] | | [[Category: Mus musculus]] |
| [[Category: Gao, F]] | | [[Category: Gao F]] |
| [[Category: Gao, G F]] | | [[Category: Gao GF]] |
| [[Category: Qi, J]] | | [[Category: Qi J]] |
| [[Category: Song, H]] | | [[Category: Song H]] |
| [[Category: Zhao, Z]] | | [[Category: Zhao Z]] |
| [[Category: Arthritogenic alphaviruse]]
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| [[Category: Chikungunya virus]]
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| [[Category: Protein binding]]
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| [[Category: Receptor]]
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| [[Category: Virus entry]]
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