6lca: Difference between revisions
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New page: '''Unreleased structure''' The entry 6lca is ON HOLD Authors: Yasukochi, S., Numoto, N., Tenno, N., Tenno, T., Ito, N., Hiroaki, H. Description: Crystal structure of human Dishevelled1... |
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==Crystal structure of human Dishevelled1 PDZ domain homotrimer== | |||
<StructureSection load='6lca' size='340' side='right'caption='[[6lca]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6lca]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LCA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LCA FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
[[Category: Hiroaki | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lca OCA], [https://pdbe.org/6lca PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lca RCSB], [https://www.ebi.ac.uk/pdbsum/6lca PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lca ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Numoto | == Disease == | ||
[[Category: Tenno | [https://www.uniprot.org/uniprot/DVL1_HUMAN DVL1_HUMAN] Autosomal dominant Robinow syndrome. The disease is caused by variants affecting the gene represented in this entry. | ||
[[Category: | == Function == | ||
[[Category: Yasukochi | [https://www.uniprot.org/uniprot/DVL1_HUMAN DVL1_HUMAN] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Hiroaki H]] | |||
[[Category: Ito N]] | |||
[[Category: Numoto N]] | |||
[[Category: Tenno N]] | |||
[[Category: Tenno T]] | |||
[[Category: Yasukochi S]] | |||
Latest revision as of 10:56, 22 November 2023
Crystal structure of human Dishevelled1 PDZ domain homotrimer
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