6k60: Difference between revisions

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<StructureSection load='6k60' size='340' side='right'caption='[[6k60]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
<StructureSection load='6k60' size='340' side='right'caption='[[6k60]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6k60]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6K60 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6k60]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K60 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.149&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6k60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k60 OCA], [http://pdbe.org/6k60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k60 RCSB], [http://www.ebi.ac.uk/pdbsum/6k60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k60 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k60 OCA], [https://pdbe.org/6k60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k60 RCSB], [https://www.ebi.ac.uk/pdbsum/6k60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k60 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>  Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref> 
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HLAG_HUMAN HLAG_HUMAN]] Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.  
[https://www.uniprot.org/uniprot/HLAG_HUMAN HLAG_HUMAN] Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6k60" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6k60" style="background-color:#fffaf0;"></div>
==See Also==
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
*[[Leukocyte immunoglobulin-like receptor|Leukocyte immunoglobulin-like receptor]]
*[[MHC 3D structures|MHC 3D structures]]
*[[MHC I 3D structures|MHC I 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Fukunaga, A]]
[[Category: Fukunaga A]]
[[Category: Fukunaga, Y]]
[[Category: Fukunaga Y]]
[[Category: Hirose, K]]
[[Category: Hirose K]]
[[Category: Kamishikiryo, J]]
[[Category: Kamishikiryo J]]
[[Category: Kanda, R]]
[[Category: Kanda R]]
[[Category: Kita, S]]
[[Category: Kita S]]
[[Category: Kuroki, K]]
[[Category: Kuroki K]]
[[Category: Maenaka, K]]
[[Category: Maenaka K]]
[[Category: Matsubara, H]]
[[Category: Matsubara H]]
[[Category: Miyashita, N]]
[[Category: Miyashita N]]
[[Category: Ose, T]]
[[Category: Ose T]]
[[Category: Shiroishi, M]]
[[Category: Shiroishi M]]
[[Category: Sugita, Y]]
[[Category: Sugita Y]]
[[Category: Hla class i]]
[[Category: Hlag]]
[[Category: Immune system]]
[[Category: Lilrb1/ilt2]]
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