6dii: Difference between revisions

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<StructureSection load='6dii' size='340' side='right'caption='[[6dii]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='6dii' size='340' side='right'caption='[[6dii]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6dii]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DII OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DII FirstGlance]. <br>
<table><tr><td colspan='2'>[[6dii]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DII OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DII FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GJY:methyl-9Z,12Z,15Z-octadecatrienylphosphonofluoridate'>GJY</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6dhv|6dhv]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GJY:methyl+(S)-(9Z,12Z,15Z)-octadeca-9,12,15-trien-1-ylphosphonofluoridate'>GJY</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FAAH, At5g64440, T12B11.3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dii OCA], [https://pdbe.org/6dii PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dii RCSB], [https://www.ebi.ac.uk/pdbsum/6dii PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dii ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fatty_acid_amide_hydrolase Fatty acid amide hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.99 3.5.1.99] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dii OCA], [http://pdbe.org/6dii PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dii RCSB], [http://www.ebi.ac.uk/pdbsum/6dii PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dii ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FAAH_ARATH FAAH_ARATH]] Degrades bioactive fatty acid amides to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Converts N-actylethanolamine (NAE) to ethanolamine. Can also use oleamide or 2-arachidonylglycerol as substrates, but not indole-3-acetamide, 1-naphtalene-acetamide, nicotinic acid amide or L-asparagine. Might be involved in abscisic acid signaling and plant defense through distinctly different mechanisms not involving the catalytic activity.<ref>PMID:12824167</ref> <ref>PMID:16880402</ref> <ref>PMID:18643971</ref> <ref>PMID:19801664</ref>
[https://www.uniprot.org/uniprot/FAAH_ARATH FAAH_ARATH] Degrades bioactive fatty acid amides to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Converts N-actylethanolamine (NAE) to ethanolamine. Can also use oleamide or 2-arachidonylglycerol as substrates, but not indole-3-acetamide, 1-naphtalene-acetamide, nicotinic acid amide or L-asparagine. Might be involved in abscisic acid signaling and plant defense through distinctly different mechanisms not involving the catalytic activity.<ref>PMID:12824167</ref> <ref>PMID:16880402</ref> <ref>PMID:18643971</ref> <ref>PMID:19801664</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Arath]]
[[Category: Arabidopsis thaliana]]
[[Category: Fatty acid amide hydrolase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Aziz, M]]
[[Category: Aziz M]]
[[Category: Bankaitis, V]]
[[Category: Bankaitis V]]
[[Category: Chapman, K D]]
[[Category: Chapman KD]]
[[Category: Tripathi, A]]
[[Category: Tripathi A]]
[[Category: Wang, X]]
[[Category: Wang X]]
[[Category: Faah]]
[[Category: Hydrolase]]
[[Category: Nae signaling]]
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