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==H3-CA-H3 tri-nucleosome with the 22 base-pair linker DNA==
==H3-CA-H3 tri-nucleosome with the 22 base-pair linker DNA==
<StructureSection load='6l49' size='340' side='right'caption='[[6l49]], [[Resolution|resolution]] 18.90&Aring;' scene=''>
<SX load='6l49' size='340' side='right' viewer='molstar' caption='[[6l49]], [[Resolution|resolution]] 18.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6l49]] is a 26 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L49 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6L49 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6l49]] is a 26 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6L49 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6l49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l49 OCA], [http://pdbe.org/6l49 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6l49 RCSB], [http://www.ebi.ac.uk/pdbsum/6l49 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6l49 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 18.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6l49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l49 OCA], [https://pdbe.org/6l49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6l49 RCSB], [https://www.ebi.ac.uk/pdbsum/6l49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6l49 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>  Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>  [[http://www.uniprot.org/uniprot/CENPA_HUMAN CENPA_HUMAN]] Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).<ref>PMID:20739937</ref> <ref>PMID:21478274</ref>
[https://www.uniprot.org/uniprot/CENPA_HUMAN CENPA_HUMAN] Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).<ref>PMID:20739937</ref> <ref>PMID:21478274</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6l49" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6l49" style="background-color:#fffaf0;"></div>
==See Also==
*[[Centromere protein 3D structure|Centromere protein 3D structure]]
*[[Histone 3D structures|Histone 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ho, C H]]
[[Category: Synthetic construct]]
[[Category: Kurumizaka, H]]
[[Category: Ho C-H]]
[[Category: Matsunami, H]]
[[Category: Kurumizaka H]]
[[Category: Ohi, M]]
[[Category: Matsunami H]]
[[Category: Tachiwana, H]]
[[Category: Ohi M]]
[[Category: Takizawa, Y]]
[[Category: Tachiwana H]]
[[Category: Wolf, M]]
[[Category: Takizawa Y]]
[[Category: Centromere]]
[[Category: Wolf M]]
[[Category: Chromatin]]
[[Category: Nuclear protein]]
[[Category: Nucleosome]]
Retrieved from "https://proteopedia.org/6l49"