1a0t: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
 
(15 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1a0t.gif|left|200px]]
<!--
The line below this paragraph, containing "STRUCTURE_1a0t", creates the "Structure Box" on the page.
You may change the PDB parameter (which sets the PDB file loaded into the applet)
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
or leave the SCENE parameter empty for the default display.
-->
{{STRUCTURE_1a0t|  PDB=1a0t  |  SCENE=  }}
'''SUCROSE-SPECIFIC PORIN, WITH BOUND SUCROSE MOLECULES'''


==SUCROSE-SPECIFIC PORIN, WITH BOUND SUCROSE MOLECULES==
<StructureSection load='1a0t' size='340' side='right'caption='[[1a0t]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1a0t]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A0T FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FRU:FRUCTOSE'>FRU</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900003:sucrose'>PRD_900003</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a0t OCA], [https://pdbe.org/1a0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a0t RCSB], [https://www.ebi.ac.uk/pdbsum/1a0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a0t ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SCRY_SALTM SCRY_SALTM] Porin for sucrose uptake.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a0/1a0t_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a0t ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The X-ray structure of a sucrose-specific porin (ScrY) from Salmonella typhimurium has been determined by multiple isomorphous replacement at 2.4 A resolution both in its uncomplexed form and with bound sucrose. ScrY is a noncrystallographic trimer of identical subunits, each with 413 structurally well-defined amino acids. A monomer is built up of 18 anti-parallel beta-strands surrounding a hydrophilic pore, with a topology closely similar to that of maltoporin. Two non-overlapping sucrose-binding sites were identified in difference Fourier maps. The higher permeability for sucrose of ScrY as compared to maltoporin is mainly accounted for by differences in their pore-lining residues.


==Overview==
Structure of the sucrose-specific porin ScrY from Salmonella typhimurium and its complex with sucrose.,Forst D, Welte W, Wacker T, Diederichs K Nat Struct Biol. 1998 Jan;5(1):37-46. PMID:9437428<ref>PMID:9437428</ref>
The X-ray structure of a sucrose-specific porin (ScrY) from Salmonella typhimurium has been determined by multiple isomorphous replacement at 2.4 A resolution both in its uncomplexed form and with bound sucrose. ScrY is a noncrystallographic trimer of identical subunits, each with 413 structurally well-defined amino acids. A monomer is built up of 18 anti-parallel beta-strands surrounding a hydrophilic pore, with a topology closely similar to that of maltoporin. Two non-overlapping sucrose-binding sites were identified in difference Fourier maps. The higher permeability for sucrose of ScrY as compared to maltoporin is mainly accounted for by differences in their pore-lining residues.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
1A0T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A0T OCA].
</div>
<div class="pdbe-citations 1a0t" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
Structure of the sucrose-specific porin ScrY from Salmonella typhimurium and its complex with sucrose., Forst D, Welte W, Wacker T, Diederichs K, Nat Struct Biol. 1998 Jan;5(1):37-46. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9437428 9437428]
*[[Porin 3D structures|Porin 3D structures]]
[[Category: Salmonella typhimurium]]
== References ==
[[Category: Single protein]]
<references/>
[[Category: Diederichs, K.]]
__TOC__
[[Category: Welte, W.]]
</StructureSection>
[[Category: Outer membrane protein]]
[[Category: Large Structures]]
[[Category: Porin]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 09:38:39 2008''
[[Category: Diederichs K]]
[[Category: Welte W]]
Retrieved from "https://proteopedia.org/1a0t"