6tkz: Difference between revisions

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'''Unreleased structure'''


The entry 6tkz is ON HOLD
==Crystal structure of the DHR2 domain of DOCK10 in complex with CDC42==
<StructureSection load='6tkz' size='340' side='right'caption='[[6tkz]], [[Resolution|resolution]] 2.64&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6tkz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TKZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.64&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tkz OCA], [https://pdbe.org/6tkz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tkz RCSB], [https://www.ebi.ac.uk/pdbsum/6tkz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tkz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DOC10_HUMAN DOC10_HUMAN] Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.[UniProtKB:Q8BZN6]


Authors: Chang, L., Yang, J., Chang, J.H., Zhang, Z., Boland, A., McLaughlin, S.H., Abu-Thuraia, A., Killoran, R.C., Smith, M.J., Cote, J.F., Barford, D.
==See Also==
 
*[[Dedicator of cytokinesis protein 3D structures|Dedicator of cytokinesis protein 3D structures]]
Description: CryoEM structure of the binary DOCK2-ELMO1 complex
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
[[Category: Unreleased Structures]]
__TOC__
[[Category: Killoran, R.C]]
</StructureSection>
[[Category: Smith, M.J]]
[[Category: Homo sapiens]]
[[Category: Boland, A]]
[[Category: Large Structures]]
[[Category: Barford, D]]
[[Category: Barford D]]
[[Category: Mclaughlin, S.H]]
[[Category: Yang, J]]
[[Category: Cote, J.F]]
[[Category: Zhang, Z]]
[[Category: Chang, J.H]]
[[Category: Chang, L]]
[[Category: Abu-Thuraia, A]]
Retrieved from "https://proteopedia.org/6tkz"