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| == Function == | | == Function == |
| '''Retinol-binding protein''' (RBP) are carrier proteins which bind retinol (vitamin A alcohol). Human RBP4 is the carrier of retinol in the blood. It delivers retinol from the liver to the peripheral tissues. RBP also functions in regulation, metabolism and activities of retinoids. Retinol is being protected from oxidation and becomes soluble when bound to RBP. RBP is classified according to its site of activity. '''Plasma RBP''' (PRBP) carries retinol in blood<ref>PMID:6994566</ref> while '''cellular RBP''' (CRBP) carries retinol in the cell<ref>PMID:2825608</ref>. | | '''Retinol-binding protein''' (RBP) are carrier proteins which bind retinol (vitamin A alcohol). Human RBP4 is the carrier of retinol in the blood. It delivers retinol from the liver to the peripheral tissues. RBP also functions in regulation, metabolism and activities of retinoids. Retinol is being protected from oxidation and becomes soluble when bound to RBP. RBP is classified according to its site of activity. '''Plasma RBP''' (PRBP) carries retinol in blood<ref>PMID:6994566</ref> while '''cellular RBP''' (CRBP) carries retinol in the cell<ref>PMID:2825608</ref>. |
| | *'''Interphotoreceptor retinoid-binding protein''' (iRBP) is involved in the regeneration of rhodopsin in the visual cycle<ref>PMID:8318167</ref>. |
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| == Relevance == | | == Relevance == |
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| </StructureSection> | | </StructureSection> |
| ==3D structures of retinol-binding protein==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *'''Plasma retinol-binding protein (PRBP)'''
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| **[[1rbp]], [[1jyd]], [[1brp]], [[1brq]] - hRBP – human<br />
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| **[[1jyj]] - hRBP (mutant)<br />
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| **[[5nty]], [[5nu2]], [[5nu6]], [[5nu7]] - hRBP IV<br />
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| **[[1aqb]] - RBP – pig<br />
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| **[[1hbq]] – bRBP – bovine<br />
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| *Plasma RBP complex
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| **[[3bsz]] - hRBP II + transthyretin + antibody + retinol<br />
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| **[[3fmz]] - hRBP IV + non-retinoid ligand<br />
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| **[[2wq9]] - hRBP IV + oleate<br />
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| **[[2wr6]] - hRBP IV + linoleate<br />
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| **[[5nu8]], [[5nu9]] - hRBP IV + palmitate<br />
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| **[[5nua]], [[5nub]] - hRBP IV + laurate<br />
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| **[[2wqa]] - hRBP IV + transthyretin + oleate<br />
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| **[[4o9s]], [[4psq]] - hRBP IV + non-retinoid<br />
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| **[[1kt3]], [[1kt4]], [[1kt5]], [[1kt6]], [[1kt7]], [[1hbp]] - bRBP + retinol <br />
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| **[[1erb]], [[1fel]], [[1fem]], [[1fen]] - bRBP + retinol derivative<br />
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| **[[1qab]] - rRBP + transthyretin<br />
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| **[[1iiu]] - RBP + retinol – chicken<br />
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| **[[1rlb]] - cRBP + transthyretin<br />
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| *'''Cellular RBP (CRBP)'''
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| **[[5h9a]], [[5ljb]], [[5ljc]], [[5ljg]], [[5ljk]] - hRBP I<br />
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| **[[5ljd]], [[5lje]], [[5ljh]] - hRBP I (mutant)<br />
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| **[[2rcq]], [[4zh9]], [[6mcv]] - hRBP II<br />
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| **[[4zgu]], [[4zh6]], [[4zr2]], [[4zcb]], [[5dg4]], [[5dpq]], [[6e7m]], [[6mcu]], [[6mkv]], [[6mlb]], [[6on5]], [[6on7]], [[6on8]], [[6e6l]], [[6e50]], [[6e51]], [[6e5e]], [[6e5q]], [[6e5r]], [[6e5s]] - hRBP II (mutant)<br />
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| **[[1ggl]] - hRBP III <br />
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| **[[1lpj]], [[6at8]] - hRBP IV<br />
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| **[[1jbh]], [[1kgl]], [[1mx7]] - rRBP I – rat - NMR<BR />
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| **[[1b4m]] - rRBP II – NMR<BR />
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| **[[1opa]] – rRBP II<br />
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| **[[1kqx]] – ZeRBP – zebrafish<br />
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| **[[4uet]] - NaRBP – Necator americanus - NMR<br />
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| *Cellular RBP complex
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| **[[5h8t]], [[5hbs]] - hRBP I + retinol<br />
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| **[[5ha1]] - hRBP I + retinol derivative<br />
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| **[[6e6m]], [[6e5l]], [[6e5t]] - hRBP I + cannabidiocrin derivative<br />
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| **[[2rct]], [[4qyn]], [[4qyp]], [[4qzt]], [[4qzu]] - hRBP II + retinol<br />
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| **[[4zj0]], [[4ruu]], [[4ede]], [[4eej]], [[4efg]], [[4exz]], [[4gkc]], [[5f6b]], [[5f7g]], [[5ffh]], [[5f58]], [[5faz]], [[5fen]], [[5u6g]] - hRBP II (mutant) + retinol<br />
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| **[[6bth]] - hRBP II (mutant) + 2-AG<br />
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| **[[6bti]] - hRBP II (mutant) + AEA<br />
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| **[[6c7z]] - hRBP II (mutant) + quinolin derivative<br />
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| **[[6e5w]] - hRBP III + cannabidiocrin derivative<br />
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| **[[1crb]], [[1opb]] - rRBP + retinol<br />
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| **[[1mx8]] - rRBP I + retinol – NMR<BR />
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| **[[1eii]] - rRBP II + retinol – NMR<BR />
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| **[[1kqw]] - ZeRBP + retinol<br />
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| **[[4xcp]] - NaRBP + palmitate<br />
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| *'''Nematode and fatty acid RBP'''
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| **[[4xcp]] - hhRBP - human hookworm<br />
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| **[[4uet]] - hhRBP - NMR<br />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |
