5qu8: Difference between revisions
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New page: '''Unreleased structure''' The entry 5qu8 is ON HOLD Authors: Burger, D., Ruf, A., Benz, J., Schlatter, D., Rudolph, M.G. Description: Category: Unreleased Structures [[Category: ... |
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==Crystal Structure of symmetric swapped human Nck SH3.1 domain, 0.93A, orthorhombic form IV== | |||
<StructureSection load='5qu8' size='340' side='right'caption='[[5qu8]], [[Resolution|resolution]] 0.93Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5qu8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QU8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QU8 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.93Å</td></tr> | |||
[[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qu8 OCA], [https://pdbe.org/5qu8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qu8 RCSB], [https://www.ebi.ac.uk/pdbsum/5qu8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qu8 ProSAT]</span></td></tr> | ||
[[ | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/NCK1_HUMAN NCK1_HUMAN] Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.<ref>PMID:10026169</ref> <ref>PMID:16835242</ref> <ref>PMID:17803907</ref> | ||
[[Category: Rudolph | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Rudolph MG]] | |||
Latest revision as of 11:28, 21 February 2024
Crystal Structure of symmetric swapped human Nck SH3.1 domain, 0.93A, orthorhombic form IV
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