6dnm: Difference between revisions

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<StructureSection load='6dnm' size='340' side='right'caption='[[6dnm]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
<StructureSection load='6dnm' size='340' side='right'caption='[[6dnm]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6dnm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DNM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DNM FirstGlance]. <br>
<table><tr><td colspan='2'>[[6dnm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DNM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DNM FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LH57_18085 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.397&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dnm OCA], [http://pdbe.org/6dnm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dnm RCSB], [http://www.ebi.ac.uk/pdbsum/6dnm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dnm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dnm OCA], [https://pdbe.org/6dnm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dnm RCSB], [https://www.ebi.ac.uk/pdbsum/6dnm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dnm ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The SecA2 protein export system is critical for the virulence of Mycobacterium tuberculosis. However, the mechanism of this export pathway remains unclear. Through a screen for suppressors of a secA2 mutant, we identified a new player in the mycobacterial SecA2 pathway that we named SatS for SecA2 (two) Suppressor. In M. tuberculosis, SatS is required for the export of a subset of SecA2 substrates and for growth in macrophages. We further identify a role for SatS as a protein export chaperone. SatS exhibits multiple properties of a chaperone, including the ability to bind to and protect substrates from aggregation. Our structural studies of SatS reveal a distinct combination of a new fold and hydrophobic grooves resembling preprotein-binding sites of the SecB chaperone. These results are significant in better defining a molecular pathway for M. tuberculosis pathogenesis and in expanding our appreciation of the diversity among chaperones and protein export systems.
Mycobacterium tuberculosis SatS is a chaperone for the SecA2 protein export pathway.,Miller BK, Hughes R, Ligon LS, Rigel NW, Malik S, Anjuwon-Foster BR, Sacchettini JC, Braunstein M Elife. 2019 Jan 3;8. pii: 40063. doi: 10.7554/eLife.40063. PMID:30604681<ref>PMID:30604681</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6dnm" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Myctu]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Hughes, R C]]
[[Category: Hughes RC]]
[[Category: Sacchettini, J C]]
[[Category: Sacchettini JC]]
[[Category: Structural genomic]]
[[Category: Chaperone]]
[[Category: Protein export]]
[[Category: PSI, Protein structure initiative]]
[[Category: Seca2]]
[[Category: Tbsgc]]
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