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==Metabotropic Glutamate Receptor 5 bound to L-quisqualate and Nb43==
==Metabotropic Glutamate Receptor 5 bound to L-quisqualate and Nb43==
<StructureSection load='6n51' size='340' side='right'caption='[[6n51]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
<SX load='6n51' size='340' side='right' viewer='molstar' caption='[[6n51]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6n51]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N51 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N51 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6n51]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N51 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N51 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=QUS:(S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC+ACID'>QUS</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6n52|6n52]], [[6n50|6n50]], [[6n4x|6n4x]], [[6n4y|6n4y]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=QUS:(S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC+ACID'>QUS</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GRM5, GPRC1E, MGLUR5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n51 OCA], [https://pdbe.org/6n51 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n51 RCSB], [https://www.ebi.ac.uk/pdbsum/6n51 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n51 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n51 OCA], [http://pdbe.org/6n51 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n51 RCSB], [http://www.ebi.ac.uk/pdbsum/6n51 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n51 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GRM5_HUMAN GRM5_HUMAN]] Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current.  
[https://www.uniprot.org/uniprot/GRM5_HUMAN GRM5_HUMAN] Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Camelus glama]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Feng, D]]
[[Category: Feng D]]
[[Category: Hu, H]]
[[Category: Hu H]]
[[Category: Kobilka, B K]]
[[Category: Kobilka BK]]
[[Category: Koehl, A]]
[[Category: Koehl A]]
[[Category: Mathiesen, J M]]
[[Category: Mathiesen JM]]
[[Category: Skiniotis, G S]]
[[Category: Skiniotis GS]]
[[Category: Sun, B]]
[[Category: Sun B]]
[[Category: Weis, W I]]
[[Category: Weis WI]]
[[Category: Cell surface receptor]]
[[Category: Membrane protein]]
Retrieved from "https://proteopedia.org/6n51"