6lk0: Difference between revisions
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==Crystal structure of human wild type TRIP13== | |||
<StructureSection load='6lk0' size='340' side='right'caption='[[6lk0]], [[Resolution|resolution]] 2.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6lk0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LK0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LK0 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lk0 OCA], [https://pdbe.org/6lk0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lk0 RCSB], [https://www.ebi.ac.uk/pdbsum/6lk0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lk0 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/PCH2_HUMAN PCH2_HUMAN] Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity). | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Chang S]] | ||
[[Category: | [[Category: Chen G]] | ||
[[Category: | [[Category: Gao L]] | ||
[[Category: | [[Category: Hu L]] | ||
[[Category: | [[Category: Huang J]] | ||
[[Category: | [[Category: Kong Y]] | ||
[[Category: | [[Category: Li B]] | ||
[[Category: | [[Category: Lian F]] | ||
[[Category: | [[Category: Mao Z]] | ||
[[Category: | [[Category: Shi J]] | ||
[[Category: | [[Category: Sun X]] | ||
[[Category: | [[Category: Tao Y]] | ||
[[Category: | [[Category: Tricot G]] | ||
[[Category: | [[Category: Wang Y]] | ||
[[Category: | [[Category: Wu X]] | ||
[[Category: | [[Category: Xiao W]] | ||
[[Category: | [[Category: Xie Y]] | ||
[[Category: | [[Category: Xu H]] | ||
[[Category: Xu Z]] | |||
[[Category: Xue H]] | |||
[[Category: Yu D]] | |||
[[Category: Zhan F]] | |||
[[Category: Zhang N]] | |||
[[Category: Zhu W]] | |||
Latest revision as of 10:46, 27 March 2024
Crystal structure of human wild type TRIP13
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