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==Anthrax Toxin Receptor 1-bound spent particles of Seneca Valley Virus in acidic conditions==
==Anthrax Toxin Receptor 1-bound spent particles of Seneca Valley Virus in acidic conditions==
<StructureSection load='6adl' size='340' side='right'caption='[[6adl]], [[Resolution|resolution]] 3.08&Aring;' scene=''>
<SX load='6adl' size='340' side='right' viewer='molstar' caption='[[6adl]], [[Resolution|resolution]] 3.08&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6adl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Senecavirus_a Senecavirus a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ADL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ADL FirstGlance]. <br>
<table><tr><td colspan='2'>[[6adl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Senecavirus_A Senecavirus A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ADL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ADL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.08&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6adl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6adl OCA], [http://pdbe.org/6adl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6adl RCSB], [http://www.ebi.ac.uk/pdbsum/6adl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6adl ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6adl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6adl OCA], [https://pdbe.org/6adl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6adl RCSB], [https://www.ebi.ac.uk/pdbsum/6adl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6adl ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/ANTR1_HUMAN ANTR1_HUMAN]] Defects in ANTXR1 are associated with susceptibility to hemangioma capillary infantile (HCI) [MIM:[http://omim.org/entry/602089 602089]]. HCI are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births. Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma.<ref>PMID:18931684</ref> 
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ANTR1_HUMAN ANTR1_HUMAN]] Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.<ref>PMID:15777794</ref> <ref>PMID:16762926</ref> 
[https://www.uniprot.org/uniprot/A0A1I9WAH6_9PICO A0A1I9WAH6_9PICO]  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Senecavirus a]]
[[Category: Senecavirus A]]
[[Category: Cao, L]]
[[Category: Cao L]]
[[Category: Lou, Z Y]]
[[Category: Lou ZY]]
[[Category: Seneca valley virus]]
[[Category: Virus]]
Retrieved from "https://proteopedia.org/6adl"