1u37: Difference between revisions
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==Auto-inhibition Mechanism of X11s/Mints Family Scaffold Proteins Revealed by the Closed Conformation of the Tandem PDZ Domains== | ==Auto-inhibition Mechanism of X11s/Mints Family Scaffold Proteins Revealed by the Closed Conformation of the Tandem PDZ Domains== | ||
<StructureSection load='1u37' size='340' side='right'caption='[[1u37 | <StructureSection load='1u37' size='340' side='right'caption='[[1u37]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1u37]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1u37]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U37 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U37 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u37 OCA], [https://pdbe.org/1u37 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u37 RCSB], [https://www.ebi.ac.uk/pdbsum/1u37 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u37 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/APBA1_HUMAN APBA1_HUMAN] Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 32: | Line 32: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chan | [[Category: Chan L-N]] | ||
[[Category: Feng | [[Category: Feng W]] | ||
[[Category: Fu | [[Category: Fu A]] | ||
[[Category: He | [[Category: He C]] | ||
[[Category: Ip | [[Category: Ip NY]] | ||
[[Category: Long | [[Category: Long J-F]] | ||
[[Category: Xia | [[Category: Xia J]] | ||
[[Category: Zhang | [[Category: Zhang M]] | ||
