5u1t: Difference between revisions

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<StructureSection load='5u1t' size='340' side='right'caption='[[5u1t]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='5u1t' size='340' side='right'caption='[[5u1t]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5u1t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U1T FirstGlance]. <br>
<table><tr><td colspan='2'>[[5u1t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5U1T FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5u1s|5u1s]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ESP1, YGR098C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), PDS1, YDR113C, YD9727.08C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5u1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u1t OCA], [https://pdbe.org/5u1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5u1t RCSB], [https://www.ebi.ac.uk/pdbsum/5u1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5u1t ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Separase Separase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.49 3.4.22.49] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u1t OCA], [http://pdbe.org/5u1t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u1t RCSB], [http://www.ebi.ac.uk/pdbsum/5u1t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u1t ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ESP1_YEAST ESP1_YEAST]] Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the MCD1/SCC1 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by securin/PDS1 protein. It also promotes anaphase spindle elongation. A component of the FEAR (CDC14 early anaphase release) network which promotes CDC14 release from the nucleolus during early anaphase. Cleaves SLK19.<ref>PMID:10403247</ref> <ref>PMID:11149918</ref> <ref>PMID:11832211</ref> <ref>PMID:9635435</ref> [[http://www.uniprot.org/uniprot/SECU_YEAST SECU_YEAST]] Regulatory protein, which plays a central role in chromosome stability. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESP1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESP1.<ref>PMID:9635435</ref> 
[https://www.uniprot.org/uniprot/ESP1_YEAST ESP1_YEAST] Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the MCD1/SCC1 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by securin/PDS1 protein. It also promotes anaphase spindle elongation. A component of the FEAR (CDC14 early anaphase release) network which promotes CDC14 release from the nucleolus during early anaphase. Cleaves SLK19.<ref>PMID:10403247</ref> <ref>PMID:11149918</ref> <ref>PMID:11832211</ref> <ref>PMID:9635435</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Baker's yeast]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Separase]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Luo, S]]
[[Category: Luo S]]
[[Category: Tong, L]]
[[Category: Tong L]]
[[Category: Chaperon]]
[[Category: Chromosome segregation]]
[[Category: Cohesion]]
[[Category: Esp1]]
[[Category: Helical region]]
[[Category: Hydrolase]]
[[Category: Inhibition]]
[[Category: Pds1]]
[[Category: Separase-securin complex]]
Retrieved from "https://proteopedia.org/5u1t"