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<StructureSection load='3zgn' size='340' side='right'caption='[[3zgn]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='3zgn' size='340' side='right'caption='[[3zgn]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3zgn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZGN FirstGlance]. <br>
<table><tr><td colspan='2'>[[3zgn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZGN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=10G:(2E)-3-METHYL-4-SULFANYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>10G</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zgl|3zgl]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=10G:(2E)-3-METHYL-4-SULFANYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>10G</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-3-methylbut-2-enyl_diphosphate_reductase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.2 1.17.1.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zgn OCA], [https://pdbe.org/3zgn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zgn RCSB], [https://www.ebi.ac.uk/pdbsum/3zgn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zgn ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zgn OCA], [http://pdbe.org/3zgn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zgn RCSB], [http://www.ebi.ac.uk/pdbsum/3zgn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zgn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI]] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref>
[https://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Barbier, E]]
[[Category: Barbier E]]
[[Category: Borel, F]]
[[Category: Borel F]]
[[Category: Ferrer, J L]]
[[Category: Dale Poulter C]]
[[Category: Janthawornpong, K]]
[[Category: Ferrer JL]]
[[Category: Kratsutsky, S]]
[[Category: Janthawornpong K]]
[[Category: Poulter, C Dale]]
[[Category: Kratsutsky S]]
[[Category: Rohmer, M]]
[[Category: Rohmer M]]
[[Category: Seemann, M]]
[[Category: Seemann M]]
[[Category: 4fe-4s cluster]]
[[Category: Inhibitor]]
[[Category: Mep pathway]]
[[Category: Oxidoreductase]]

Latest revision as of 17:49, 8 September 2026

Crystal structures of Escherichia coli IspH in complex with TMBPP a potent inhibitor of the methylerythritol phosphate pathway

3zgn, resolution 1.95Å

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