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==Solution structure of the yeast Ddi1 HDD domain==
==Solution structure of the yeast Ddi1 HDD domain==
<StructureSection load='5kes' size='340' side='right'caption='[[5kes]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='5kes' size='340' side='right'caption='[[5kes]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5kes]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KES OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KES FirstGlance]. <br>
<table><tr><td colspan='2'>[[5kes]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KES OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KES FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DDI1, VSM1, YER143W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kes OCA], [https://pdbe.org/5kes PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kes RCSB], [https://www.ebi.ac.uk/pdbsum/5kes PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kes ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kes OCA], [http://pdbe.org/5kes PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kes RCSB], [http://www.ebi.ac.uk/pdbsum/5kes PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kes ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DDI1_YEAST DDI1_YEAST]] Acts as a linker between the 19S proteasome and polyubiquitinated proteins like the HO endonuclease and UFO1 via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control. Appears to act as negative regulator of constitutive exocytosis. May act at the level of secretory vesicle docking and fusion as a competitive inhibitor of SNARE assembly.<ref>PMID:10330187</ref> <ref>PMID:11238935</ref> <ref>PMID:12051757</ref> <ref>PMID:12925750</ref> <ref>PMID:15964793</ref> <ref>PMID:17144915</ref> <ref>PMID:16478980</ref>
[https://www.uniprot.org/uniprot/DDI1_YEAST DDI1_YEAST] Acts as a linker between the 19S proteasome and polyubiquitinated proteins like the HO endonuclease and UFO1 via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control. Appears to act as negative regulator of constitutive exocytosis. May act at the level of secretory vesicle docking and fusion as a competitive inhibitor of SNARE assembly.<ref>PMID:10330187</ref> <ref>PMID:11238935</ref> <ref>PMID:12051757</ref> <ref>PMID:12925750</ref> <ref>PMID:15964793</ref> <ref>PMID:17144915</ref> <ref>PMID:16478980</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Baker's yeast]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Gehring, K]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Ratcliffe, C]]
[[Category: Gehring K]]
[[Category: Saskova, K]]
[[Category: Ratcliffe C]]
[[Category: Trempe, J F]]
[[Category: Saskova K]]
[[Category: Veverka, V]]
[[Category: Trempe J-F]]
[[Category: Dna repair]]
[[Category: Veverka V]]
[[Category: Helical bundle]]
[[Category: Unknown function]]
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