6loh: Difference between revisions
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==Crystal structure of the catalytic domain of human ubiquitin ligase AREL1== | |||
<StructureSection load='6loh' size='340' side='right'caption='[[6loh]], [[Resolution|resolution]] 3.21Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6loh]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LOH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LOH FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.207Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6loh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6loh OCA], [https://pdbe.org/6loh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6loh RCSB], [https://www.ebi.ac.uk/pdbsum/6loh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6loh ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/AREL1_HUMAN AREL1_HUMAN] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation.<ref>PMID:23479728</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Chen ZZ]] | |||
[[Category: Li ZH]] | |||
[[Category: Shang GH]] | |||
Latest revision as of 10:46, 27 March 2024
Crystal structure of the catalytic domain of human ubiquitin ligase AREL1
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