6lp5: Difference between revisions
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New page: '''Unreleased structure''' The entry 6lp5 is ON HOLD Authors: Su, X.R., Ming, T.H., Su, C. Description: Structure of Sinonovacula constricta ferritin [[Category: Unreleased Structures]... |
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==Structure of Sinonovacula constricta ferritin== | |||
<StructureSection load='6lp5' size='340' side='right'caption='[[6lp5]], [[Resolution|resolution]] 1.98Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6lp5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Sinonovacula_constricta Sinonovacula constricta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LP5 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lp5 OCA], [https://pdbe.org/6lp5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lp5 RCSB], [https://www.ebi.ac.uk/pdbsum/6lp5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lp5 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/D2JIV0_SINCO D2JIV0_SINCO] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.[RuleBase:RU361145] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Ferritins are ubiquitous iron-binding proteins that are mainly related to iron storage, detoxification and innate immunity. Here, we present the crystal structure of a marine invertebrate ferritin from Sinonovacula constricta at a resolution of 1.98 A. The S. constricta ferritin (ScFer) possessed some structural similarities with vertebrate ferritins, and they shared a well-conserved architecture composed of five alpha-helical bundles that assembled into a cage-like structure with 24-subunits. The structure of ScFer also showed iron binding sites in the 3-fold channel, ferroxidase center, and putative nucleation sites. Further, electrostatic potential calculations suggested that the electrostatic gradient of the 3-fold channel could provide a guidance mechanism for iron entering the ferritin cavity. | |||
Crystallographic characterization of ferritin from Sinonovacula constricta.,Su C, Ming T, Wu Y, Jiang Q, Huan H, Lu C, Zhou J, Li Y, Song H, Su X Biochem Biophys Res Commun. 2020 Mar 26;524(1):217-223. doi:, 10.1016/j.bbrc.2020.01.069. Epub 2020 Jan 23. PMID:31983429<ref>PMID:31983429</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: Ming | <div class="pdbe-citations 6lp5" style="background-color:#fffaf0;"></div> | ||
[[Category: Su | |||
[[Category: Su | ==See Also== | ||
*[[Ferritin 3D structures|Ferritin 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Sinonovacula constricta]] | |||
[[Category: Ming TH]] | |||
[[Category: Su C]] | |||
[[Category: Su XR]] | |||
