6xvx: Difference between revisions
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New page: '''Unreleased structure''' The entry 6xvx is ON HOLD Authors: Merlino, A., Ferraro, G. Description: X-ray structure obtained upon reaction of dirhodium tetraacetate with RNase A (high ... |
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==X-ray structure obtained upon reaction of dirhodium tetraacetate with RNase A (high resolution)== | |||
<StructureSection load='6xvx' size='340' side='right'caption='[[6xvx]], [[Resolution|resolution]] 1.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6xvx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XVX FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=RH3:RHODIUM(III)+ION'>RH3</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xvx OCA], [https://pdbe.org/6xvx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xvx RCSB], [https://www.ebi.ac.uk/pdbsum/6xvx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xvx ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The interactions between the cytotoxic paddlewheel dirhodium complex [Rh2(mu-O2CCH3)4] and the model protein bovine pancreatic ribonuclease (RNase A) were investigated by high-resolution mass spectrometry and X-ray crystallography. The results indicate that [Rh2(mu-O2CCH3)4] extensively reacts with RNase A. The metal compound binds the protein via coordination of the imidazole ring of a His side chain to one of its axial sites, while the dirhodium center and the acetato ligands remain unmodified. Data provide valuable information for the design of artificial dirhodium-containing metalloenzymes. | |||
Protein interactions of dirhodium tetraacetate: a structural study.,Ferraro G, Pratesi A, Messori L, Merlino A Dalton Trans. 2020 Feb 5. doi: 10.1039/c9dt04819g. PMID:32022076<ref>PMID:32022076</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: Ferraro | <div class="pdbe-citations 6xvx" style="background-color:#fffaf0;"></div> | ||
[[Category: Merlino | |||
==See Also== | |||
*[[Ribonuclease 3D structures|Ribonuclease 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bos taurus]] | |||
[[Category: Large Structures]] | |||
[[Category: Ferraro G]] | |||
[[Category: Merlino A]] | |||
Latest revision as of 13:13, 24 January 2024
X-ray structure obtained upon reaction of dirhodium tetraacetate with RNase A (high resolution)
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