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<StructureSection load='4tqu' size='340' side='right'caption='[[4tqu]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='4tqu' size='340' side='right'caption='[[4tqu]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4tqu]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhizomonas_sp. Rhizomonas sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TQU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TQU FirstGlance]. <br>
<table><tr><td colspan='2'>[[4tqu]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Sphingomonas_sp. Sphingomonas sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TQU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TQU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEM:BETA-D-MANNURONIC+ACID'>BEM</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAW:4-DEOXY-ALPHA-L-ERYTHRO-HEX-4-ENOPYRANURONIC+ACID'>MAW</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.204&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4tqv|4tqv]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEM:BETA-D-MANNURONIC+ACID'>BEM</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAW:4-DEOXY-ALPHA-L-ERYTHRO-HEX-4-ENOPYRANURONIC+ACID'>MAW</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">algM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28214 Rhizomonas sp.]), algM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28214 Rhizomonas sp.]), algS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28214 Rhizomonas sp.]), algQ2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28214 Rhizomonas sp.])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tqu OCA], [https://pdbe.org/4tqu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tqu RCSB], [https://www.ebi.ac.uk/pdbsum/4tqu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tqu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tqu OCA], [http://pdbe.org/4tqu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tqu RCSB], [http://www.ebi.ac.uk/pdbsum/4tqu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tqu ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/Q9KWT8_SPHSX Q9KWT8_SPHSX]
The acidic polysaccharide alginate represents a promising marine biomass for the microbial production of biofuels, although the molecular and structural characteristics of alginate transporters remain to be clarified. In Sphingomonas sp. A1, the ATP-binding cassette transporter AlgM1M2SS is responsible for the import of alginate across the cytoplasmic membrane. Here, we present the substrate-transport characteristics and quaternary structure of AlgM1M2SS. The addition of poly- or oligoalginate enhanced the ATPase activity of reconstituted AlgM1M2SS coupled with one of the periplasmic solute-binding proteins, AlgQ1 or AlgQ2. External fluorescence-labeled oligoalginates were specifically imported into AlgM1M2SS-containing proteoliposomes in the presence of AlgQ2, ATP, and Mg2+. The crystal structure of AlgQ2-bound AlgM1M2SS adopts an inward-facing conformation. The interaction between AlgQ2 and AlgM1M2SS induces the formation of an alginate-binding tunnel-like structure accessible to the solvent. The translocation route inside the transmembrane domains contains charged residues suitable for the import of acidic saccharides.
 
Structure of a Bacterial ABC Transporter Involved in the Import of an Acidic Polysaccharide Alginate.,Maruyama Y, Itoh T, Kaneko A, Nishitani Y, Mikami B, Hashimoto W, Murata K Structure. 2015 Jul 21. pii: S0969-2126(15)00274-9. doi:, 10.1016/j.str.2015.06.021. PMID:26235029<ref>PMID:26235029</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4tqu" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Rhizomonas sp]]
[[Category: Sphingomonas sp]]
[[Category: Hashimoto, W]]
[[Category: Hashimoto W]]
[[Category: Itoh, T]]
[[Category: Itoh T]]
[[Category: Kaneko, A]]
[[Category: Kaneko A]]
[[Category: Maruyama, Y]]
[[Category: Maruyama Y]]
[[Category: Mikami, B]]
[[Category: Mikami B]]
[[Category: Murata, K]]
[[Category: Murata K]]
[[Category: Nishitani, Y]]
[[Category: Nishitani Y]]
[[Category: Abc]]
[[Category: Alginate]]
[[Category: Sphingomona]]
[[Category: Transport protein]]
[[Category: Transporter]]
Retrieved from "https://proteopedia.org/4tqu"