Syntaxin: Difference between revisions

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__TOC__

== Function ==

'''Syntaxin''' (Stx) are membrane-integrated proteins that are instrumental in exocytosis of vesicles. Stx-1 is essential for the formation of the SNARE complex involved in the fusion machinery in the brain. Stx-1 forms a 4-helical bundle complex with proteins SNAP-25 and VAMP2 which drives fusion of vesicles with the plasma membrane<ref>PMID:26903802</ref>. The coiled-coil bundle structure is formed by the interactions of the complex SNARE motifs<ref>PMID:24218570</ref>.

'''Syntaxin''' (Stx) are membrane-integrated proteins that are instrumental in exocytosis of vesicles.

*'''Stx-1''' is essential for the formation of the SNARE complex involved in the fusion machinery in the brain. Stx-1 forms a 4-helical bundle complex with proteins SNAP-25 and VAMP2 which drives fusion of vesicles with the plasma membrane<ref>PMID:26903802</ref>. The coiled-coil bundle structure is formed by the interactions of the complex SNARE motifs<ref>PMID:24218570</ref>.

*'''Stx-1A''' regulates the function of transmembrane proteins like ion channels and neurotransmitter transporters<ref>PMID:18617632</ref>.

*'''Stx-6''' is a SNARE protein involved in a variety of internal membrane fusion events.

*'''Stx-7''' is involved in endosomal membrane fusion<ref>PMID:34408265</ref>.

*'''Stx-10''' is a SNARE protein localised to the trans-Golgi network<ref>PMID:16154903</ref>.

*'''Stx-12''' is a SNARE protein localised to the endosome<ref>PMID:9507000</ref>.

*'''Stx-13''' has a role in membrane expansion during neuronal development <ref>PMID:10886332</ref>.

*'''Stx-17''' is required for autophagosome-lysosome fusion<ref>PMID:23466629</ref>.

*'''Stx-VAM3P''' is involved invacuolar assembly<ref>PMID:9202390</ref>.

== Relevance ==

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==3D structures of syntaxin==

[[Syntaxin 3D structures]]

~~</StructureSection>~~

== References ==

</StructureSection>

[[Category:Topic Page]]

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 <StructureSection load='3ipd' size='450' side='right' caption='Rat Syntaxin 1a SNARE motif (green) complex with VAMP2 SNARE motif (cyan) and SNAP25 SNARE motif (pink and yellow) (PDB code [[3ipd]])' scene='80/801795/Cv/5'>
+__TOC__
 == Function ==
-'''Syntaxin''' (Stx) are membrane-integrated proteins that are instrumental in exocytosis of vesicles.  Stx-1 is essential for the formation of the SNARE complex involved in the fusion machinery in the brain.  Stx-1 forms a 4-helical bundle complex with proteins SNAP-25 and VAMP2 which drives fusion of vesicles with the plasma membrane<ref>PMID:26903802</ref>.  The coiled-coil bundle structure is formed by the interactions of the complex SNARE motifs<ref>PMID:24218570</ref>.
+'''Syntaxin''' (Stx) are membrane-integrated proteins that are instrumental in exocytosis of vesicles.
+*'''Stx-1''' is essential for the formation of the SNARE complex involved in the fusion machinery in the brain.  Stx-1 forms a 4-helical bundle complex with proteins SNAP-25 and VAMP2 which drives fusion of vesicles with the plasma membrane<ref>PMID:26903802</ref>.  The coiled-coil bundle structure is formed by the interactions of the complex SNARE motifs<ref>PMID:24218570</ref>.
+*'''Stx-1A''' regulates the function of transmembrane proteins like ion channels and neurotransmitter transporters<ref>PMID:18617632</ref>.
+*'''Stx-6''' is a SNARE protein involved in a variety of internal membrane fusion events.
+*'''Stx-7''' is involved in endosomal membrane fusion<ref>PMID:34408265</ref>.
+*'''Stx-10''' is a SNARE protein localised to the trans-Golgi network<ref>PMID:16154903</ref>.
+*'''Stx-12''' is a SNARE protein localised to the endosome<ref>PMID:9507000</ref>.
+*'''Stx-13''' has a role in membrane expansion during neuronal development <ref>PMID:10886332</ref>.
+*'''Stx-17''' is required for autophagosome-lysosome fusion<ref>PMID:23466629</ref>.
+*'''Stx-VAM3P''' is involved invacuolar assembly<ref>PMID:9202390</ref>.
 == Relevance ==
@@ Line 15: / Line 24: @@
 ==3D structures of syntaxin==
 [[Syntaxin 3D structures]]
-</StructureSection>
 == References ==
 <references/>
+</StructureSection>
 [[Category:Topic Page]]