5qxt: Difference between revisions
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New page: '''Unreleased structure''' The entry 5qxt is ON HOLD Authors: Snee, M., Talon, R., Fowley, D., Collins, P., Nelson, A., Arrowsmith, C.H., Bountra, C., Edwards, A., Von-Delft, F. Descri... |
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==PanDDA analysis group deposition -- Crystal Structure of ATAD2 in complex with JKH47== | |||
<StructureSection load='5qxt' size='340' side='right'caption='[[5qxt]], [[Resolution|resolution]] 1.55Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5qxt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QXT FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=RJ7:ethyl+(2S,3S)-2-fluoro-3-hydroxy-3-(pyridin-3-yl)propanoate'>RJ7</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qxt OCA], [https://pdbe.org/5qxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qxt RCSB], [https://www.ebi.ac.uk/pdbsum/5qxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qxt ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref> | |||
==See Also== | |||
*[[ATPase family AAA domain-containing protein|ATPase family AAA domain-containing protein]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Arrowsmith CH]] | ||
[[Category: Nelson | [[Category: Bountra C]] | ||
[[Category: | [[Category: Collins P]] | ||
[[Category: Talon | [[Category: Edwards A]] | ||
[[Category: Von-Delft | [[Category: Fowley D]] | ||
[[Category: Nelson A]] | |||
[[Category: Snee M]] | |||
[[Category: Talon R]] | |||
[[Category: Von-Delft F]] | |||
Latest revision as of 11:28, 21 February 2024
PanDDA analysis group deposition -- Crystal Structure of ATAD2 in complex with JKH47
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