6o6e: Difference between revisions
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==Crystal structure of PltF trapped with PltL using a proline adenosine vinylsulfonamide inhibitor== | |||
<StructureSection load='6o6e' size='340' side='right'caption='[[6o6e]], [[Resolution|resolution]] 2.14Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6o6e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_protegens_Pf-5 Pseudomonas protegens Pf-5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O6E FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.14Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=I5M:(2~{R})-~{N}-[3-[2-[(1~{S})-2-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfamoyl]-1-[(2~{S})-pyrrolidin-2-yl]ethyl]sulfanylethylamino]-3-oxidanylidene-propyl]-3,3-dimethyl-2-oxidanyl-4-phosphooxy-butanamide'>I5M</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o6e OCA], [https://pdbe.org/6o6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o6e RCSB], [https://www.ebi.ac.uk/pdbsum/6o6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o6e ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PLTF_PSEF5 PLTF_PSEF5] Involved in the biosynthesis of pyoluteorin. Catalyzes the conversion of L-proline to L-prolyl-AMP and the transfer of the L-prolyl group to acyl carrier protein PltL.<ref>PMID:11880032</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Using a covalent chemical probe and X-ray crystallography coupled to nuclear magnetic resonance data, we elucidated the dynamic molecular basis of protein recognition between the carrier protein and adenylation domain in pyoluteorin biosynthesis. These findings reveal a unique binding mode, which contrasts previously solved carrier protein and partner protein interfaces. | |||
Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis.,Corpuz JC, Podust LM, Davis TD, Jaremko MJ, Burkart MD RSC chem biol. 2020 Apr 1;1(1):8-12. doi: 10.1039/c9cb00015a. Epub 2020 Mar 24. PMID:33305272<ref>PMID:33305272</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6o6e" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Pseudomonas protegens Pf-5]] | |||
[[Category: Corpuz JC]] | |||
[[Category: Podust LM]] | |||
Latest revision as of 10:17, 23 October 2024
Crystal structure of PltF trapped with PltL using a proline adenosine vinylsulfonamide inhibitor
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