6y1e: Difference between revisions
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New page: '''Unreleased structure''' The entry 6y1e is ON HOLD until sometime in the future Authors: Pandian, R., Worth, R., Thangaraj, V., Sayed, Y., Dirr, H.W. Description: Crystal structure o... |
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==Crystal structure of human glutathione transferase P1-1 (hGSTP1-1) that was co-crystallised in the presence of indanyloxyacetic acid-94 (IAA-94)== | |||
<StructureSection load='6y1e' size='340' side='right'caption='[[6y1e]], [[Resolution|resolution]] 1.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6y1e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y1E FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.402Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=O7Z:2-[[6,7-bis(chloranyl)-2-cyclopentyl-2-methyl-1-oxidanylidene-3~{H}-inden-5-yl]oxy]ethanoic+acid'>O7Z</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y1e OCA], [https://pdbe.org/6y1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y1e RCSB], [https://www.ebi.ac.uk/pdbsum/6y1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y1e ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<ref>PMID:21668448</ref> | |||
==See Also== | |||
*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Dirr | __TOC__ | ||
[[Category: Pandian | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Worth | [[Category: Dirr HW]] | ||
[[Category: Pandian R]] | |||
[[Category: Sayed Y]] | |||
[[Category: Thangaraj V]] | |||
[[Category: Worth R]] | |||
Latest revision as of 13:17, 24 January 2024
Crystal structure of human glutathione transferase P1-1 (hGSTP1-1) that was co-crystallised in the presence of indanyloxyacetic acid-94 (IAA-94)
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