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==Identification and Characterization of a carboxypeptidase inhibitor from Lycium barbarum==
==Identification and Characterization of a carboxypeptidase inhibitor from Lycium barbarum==
<StructureSection load='6jic' size='340' side='right'caption='[[6jic]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='6jic' size='340' side='right'caption='[[6jic]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6jic]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lycium_barbarum Lycium barbarum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JIC FirstGlance]. <br>
<table><tr><td colspan='2'>[[6jic]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lycium_barbarum Lycium barbarum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JIC FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jic OCA], [http://pdbe.org/6jic PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jic RCSB], [http://www.ebi.ac.uk/pdbsum/6jic PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jic ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jic OCA], [https://pdbe.org/6jic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jic RCSB], [https://www.ebi.ac.uk/pdbsum/6jic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jic ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Hyperstable cysteine-rich peptides (CRPs) represent an underexplored superfamily of bioactives in functional foods. An example is wolfberry of the Lycium barbarum family. Previously, we discovered a CRP, designated alpha-lybatide, from L. barbarum bark. Herein, we report the discovery of beta-lybatide, a novel carboxypeptidase inhibitor belonging to a different CRP family from the wolfberry plant. Proteomic and transcriptomic analyses showed that beta-lybatide contains 36 amino acids with six cysteine residues. NMR spectroscopy revealed that beta-lybatide displays a knottin-like structure that renders it highly resistant to thermal, chemical and enzymatic degradation, conditions important for keeping its structural integrity in gastrointestinal tract. Biochemical assays showed that beta-lybatide is a potent carboxypeptidase inhibitor which could contribute to the wolfberry biological activities. Bioinformatics analysis revealed an additional 49 beta-lybatide-like plant carboxypeptidase inhibitors. Together, our results show that beta-lybatide is the first and the smallest plant-derived hyperstable carboxypeptidase inhibitor discovered from a functional food.
Identification and characterization of a wolfberry carboxypeptidase inhibitor from Lycium barbarum.,Huang J, Wong KH, Tan WL, Tay SV, Wang S, Tam JP Food Chem. 2021 Feb 19;351:129338. doi: 10.1016/j.foodchem.2021.129338. PMID:33647700<ref>PMID:33647700</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6jic" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lycium barbarum]]
[[Category: Lycium barbarum]]
[[Category: Huang, J Y]]
[[Category: Huang JY]]
[[Category: Tan, W L]]
[[Category: Tan WL]]
[[Category: Tay, S V]]
[[Category: Tay SV]]
[[Category: Wang, S J]]
[[Category: Wang SJ]]
[[Category: Wong, K H]]
[[Category: Wong KH]]
[[Category: Carboxypeptidase inhibitor]]
[[Category: Cysteine-rich peptide]]
[[Category: Plant protein]]
[[Category: Wolfberry]]
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