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[[Image:1anv.gif|left|200px]]
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{{STRUCTURE_1anv|  PDB=1anv  |  SCENE=  }}
'''ADENOVIRUS 5 DBP/URANYL FLUORIDE SOAK'''


==ADENOVIRUS 5 DBP/URANYL FLUORIDE SOAK==
<StructureSection load='1anv' size='340' side='right'caption='[[1anv]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1anv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_adenovirus_5 Human adenovirus 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ANV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ANV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IUM:URANYL+(VI)+ION'>IUM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1anv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1anv OCA], [https://pdbe.org/1anv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1anv RCSB], [https://www.ebi.ac.uk/pdbsum/1anv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1anv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DNB2_ADE05 DNB2_ADE05] Binds cooperatively single-stranded DNA in a sequence-independent manner. Involved in DNA-replication, regulation of mRNA formation, and host-range specificity. Zinc is required for DNA binding.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/an/1anv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1anv ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Soaking crystals of the C-terminal DNA-binding domain of the adenovirus single-stranded DNA-binding protein with a buffer containing K(3)UO(2)F(5) results in a 9% change of the crystallographic c axis without destruction of the crystals or appreciable loss of resolution. The crystals belong to space group P2(1)2(1)2(1) with a = 79.7, b = 75.6 and c = 60.6 A. The three-dimensional structure has been refined to 2.7 A with a crystallographic R factor of 0.206. Antiparallel chains of protein molecules running through the entire crystal are linked by uranyl ions. The relative orientation of protein monomers is flexible, even in the crystalline state, and allows changes in the packing of the protein chains.


==Overview==
Conformational change of the adenovirus DNA-binding protein induced by soaking crystals with K3UO2F5 solutions.,Kanellopoulos PN, Tsernoglou D, van der Vliet PC, Tucker PA Acta Crystallogr D Biol Crystallogr. 1996 Sep 1;52(Pt 5):942-5. PMID:15299602<ref>PMID:15299602</ref>
Soaking crystals of the C-terminal DNA-binding domain of the adenovirus single-stranded DNA-binding protein with a buffer containing K(3)UO(2)F(5) results in a 9% change of the crystallographic c axis without destruction of the crystals or appreciable loss of resolution. The crystals belong to space group P2(1)2(1)2(1) with a = 79.7, b = 75.6 and c = 60.6 A. The three-dimensional structure has been refined to 2.7 A with a crystallographic R factor of 0.206. Antiparallel chains of protein molecules running through the entire crystal are linked by uranyl ions. The relative orientation of protein monomers is flexible, even in the crystalline state, and allows changes in the packing of the protein chains.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
1ANV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_adenovirus_5 Human adenovirus 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ANV OCA].
</div>
<div class="pdbe-citations 1anv" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
Conformational change of the adenovirus DNA-binding protein induced by soaking crystals with K3UO2F5 solutions., Kanellopoulos PN, Tsernoglou D, van der Vliet PC, Tucker PA, Acta Crystallogr D Biol Crystallogr. 1996 Sep 1;52(Pt 5):942-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15299602 15299602]
*[[Single-stranded DNA-binding protein 3D structures|Single-stranded DNA-binding protein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human adenovirus 5]]
[[Category: Human adenovirus 5]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Kanellopoulos, P N.]]
[[Category: Kanellopoulos PN]]
[[Category: Tsernoglou, D.]]
[[Category: Tsernoglou D]]
[[Category: Tucker, P A.]]
[[Category: Tucker PA]]
[[Category: Vliet, P C.Van Der.]]
[[Category: Van Der Vliet PC]]
[[Category: Dna-binding protein]]
[[Category: Early protein]]
[[Category: Nuclear protein]]
[[Category: Phosphorylation]]
[[Category: Zinc-finger]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:29:26 2008''

Latest revision as of 05:22, 13 August 2026

ADENOVIRUS 5 DBP/URANYL FLUORIDE SOAK

1anv, resolution 2.70Å

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