2qu4: Difference between revisions

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<SX load='2qu4' size='340' side='right' viewer='molstar' caption='[[2qu4]], [[Resolution|resolution]] 16.00&Aring;' scene=''>
<SX load='2qu4' size='340' side='right' viewer='molstar' caption='[[2qu4]], [[Resolution|resolution]] 16.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2qu4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QU4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QU4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2qu4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QU4 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qu4 OCA], [http://pdbe.org/2qu4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qu4 RCSB], [http://www.ebi.ac.uk/pdbsum/2qu4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qu4 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 16&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qu4 OCA], [https://pdbe.org/2qu4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qu4 RCSB], [https://www.ebi.ac.uk/pdbsum/2qu4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qu4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PARM_ECOLX PARM_ECOLX]] Involved in the control of plasmid partition. Required for the accurate segregation of the plasmid.  
[https://www.uniprot.org/uniprot/PARM_ECOLX PARM_ECOLX] Involved in the control of plasmid partition. Required for the accurate segregation of the plasmid.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qu4 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qu4 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Bacterial ParM is a homolog of eukaryotic actin and is involved in moving plasmids so that they segregate properly during cell division. Using cryo-EM and three-dimensional reconstruction, we show that ParM filaments have a different structure from F-actin, with very different subunit-subunit interfaces. These interfaces result in the helical handedness of the ParM filament being opposite to that of F-actin. Like F-actin, ParM filaments have a variable twist, and we show that this involves domain-domain rotations within the ParM subunit. The present results yield new insights into polymorphisms within F-actin, as well as the evolution of polymer families.
The structure of bacterial ParM filaments.,Orlova A, Garner EC, Galkin VE, Heuser J, Mullins RD, Egelman EH Nat Struct Mol Biol. 2007 Oct;14(10):921-6. Epub 2007 Sep 16. PMID:17873883<ref>PMID:17873883</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2qu4" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Plasmid segregation protein ParM|Plasmid segregation protein ParM]]
*[[Plasmid segregation protein ParM|Plasmid segregation protein ParM]]
== References ==
<references/>
__TOC__
__TOC__
</SX>
</SX>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Egelman, E H]]
[[Category: Egelman EH]]
[[Category: Galkin, V E]]
[[Category: Galkin VE]]
[[Category: Garner, E C]]
[[Category: Garner EC]]
[[Category: Heuser, J]]
[[Category: Heuser J]]
[[Category: Mullins, R D]]
[[Category: Mullins RD]]
[[Category: Orlova, A]]
[[Category: Orlova A]]
[[Category: Actin-like protein]]
[[Category: Filament model]]
[[Category: Helical polymer]]
[[Category: Plasmid]]
[[Category: Plasmid partition]]
[[Category: Structural protein]]
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