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<SX load='3j89' size='340' side='right' viewer='molstar' caption='[[3j89]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
<SX load='3j89' size='340' side='right' viewer='molstar' caption='[[3j89]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3j89]] is a 19 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J89 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3j89]] is a 19 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J89 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j89 OCA], [http://pdbe.org/3j89 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3j89 RCSB], [http://www.ebi.ac.uk/pdbsum/3j89 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3j89 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j89 OCA], [https://pdbe.org/3j89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j89 RCSB], [https://www.ebi.ac.uk/pdbsum/3j89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j89 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Numerous instances can be seen in evolution in which protein quaternary structures have diverged while the sequences of the building blocks have remained fairly conserved. However, the path through which such divergence has taken place is usually not known. We have designed two synthetic 29-residue alpha-helical peptides, based on the coiled-coil structural motif, that spontaneously self-assemble into helical nanotubes in vitro. Using electron cryomicroscopy with a newly available direct electron detection capability, we can achieve near-atomic resolution of these thin structures. We show how conservative changes of only one or two amino acids result in dramatic changes in quaternary structure, in which the assemblies can be switched between two very different forms. This system provides a framework for understanding how small sequence changes in evolution can translate into very large changes in supramolecular structure, a phenomenon that may have significant implications for the de novo design of synthetic peptide assemblies.
Structural plasticity of helical nanotubes based on coiled-coil assemblies.,Egelman EH, Xu C, DiMaio F, Magnotti E, Modlin C, Yu X, Wright E, Baker D, Conticello VP Structure. 2015 Feb 3;23(2):280-9. doi: 10.1016/j.str.2014.12.008. Epub 2015 Jan , 22. PMID:25620001<ref>PMID:25620001</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3j89" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</SX>
</SX>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Baker, D]]
[[Category: Synthetic construct]]
[[Category: Conticello, V P]]
[[Category: Baker D]]
[[Category: DiMaio, F]]
[[Category: Conticello VP]]
[[Category: Egelman, E H]]
[[Category: DiMaio F]]
[[Category: Magnotti, E]]
[[Category: Egelman EH]]
[[Category: Modlin, C]]
[[Category: Magnotti E]]
[[Category: Wright, E]]
[[Category: Modlin C]]
[[Category: Xu, C]]
[[Category: Wright E]]
[[Category: Yu, X]]
[[Category: Xu C]]
[[Category: Coiled-coil]]
[[Category: Yu X]]
[[Category: Helical filament]]
[[Category: Nanotube]]
[[Category: Synthetic peptide]]

Latest revision as of 10:11, 21 February 2024

Structural Plasticity of Helical Nanotubes Based on Coiled-Coil Assemblies

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