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[[Image:1aoj.gif|left|200px]]
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{{STRUCTURE_1aoj|  PDB=1aoj  |  SCENE=  }}
'''THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER'''


==THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER==
<StructureSection load='1aoj' size='340' side='right'caption='[[1aoj]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1aoj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AOJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AOJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aoj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aoj OCA], [https://pdbe.org/1aoj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aoj RCSB], [https://www.ebi.ac.uk/pdbsum/1aoj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aoj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/EPS8_MOUSE EPS8_MOUSE] Upon binding to EGF receptor/EGFR enhances EGF-dependent mitogenic signals. Can bind multiple cellular targets.<ref>PMID:8404850</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ao/1aoj_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aoj ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
SH3 domains are structurally well-characterized as monomeric modular units of protein structure that mediate protein-protein recognition in numerous signal transduction proteins. The X-ray crystallographic structure of the Eps8 SH3 domain reveals a novel variation of the canonical SH3 fold: the SH3 domain from Eps8 is a dimer formed by strand interchange. In addition, co-immunoprecipitation experiments show that intact Eps8 is multimeric in vivo. Hence, the SH3 domain of Eps8 may represent a dimerization motif.


==Overview==
The SH3 domain of Eps8 exists as a novel intertwined dimer.,Kishan KV, Scita G, Wong WT, Di Fiore PP, Newcomer ME Nat Struct Biol. 1997 Sep;4(9):739-43. PMID:9303002<ref>PMID:9303002</ref>
SH3 domains are structurally well-characterized as monomeric modular units of protein structure that mediate protein-protein recognition in numerous signal transduction proteins. The X-ray crystallographic structure of the Eps8 SH3 domain reveals a novel variation of the canonical SH3 fold: the SH3 domain from Eps8 is a dimer formed by strand interchange. In addition, co-immunoprecipitation experiments show that intact Eps8 is multimeric in vivo. Hence, the SH3 domain of Eps8 may represent a dimerization motif.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
1AOJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AOJ OCA].
</div>
<div class="pdbe-citations 1aoj" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
The SH3 domain of Eps8 exists as a novel intertwined dimer., Kishan KV, Scita G, Wong WT, Di Fiore PP, Newcomer ME, Nat Struct Biol. 1997 Sep;4(9):739-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9303002 9303002]
*[[Epidermal growth factor receptor substrate 3D structures|Epidermal growth factor receptor substrate 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Kishan KVR]]
[[Category: Kishan, K V.R.]]
[[Category: Newcomer ME]]
[[Category: Newcomer, M E.]]
[[Category: Eps8]]
[[Category: Proline rich peptide]]
[[Category: Sh3 domain]]
[[Category: Signal transduction]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:31:00 2008''
Retrieved from "https://proteopedia.org/1aoj"