5urf: Difference between revisions
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<SX load='5urf' size='340' side='right' viewer='molstar' caption='[[5urf]], [[Resolution|resolution]] 2.90Å' scene=''> | <SX load='5urf' size='340' side='right' viewer='molstar' caption='[[5urf]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5urf]] is a 60 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5urf]] is a 60 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_bocavirus_1 Human bocavirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5URF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5URF FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5urf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5urf OCA], [https://pdbe.org/5urf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5urf RCSB], [https://www.ebi.ac.uk/pdbsum/5urf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5urf ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/CAPSD_HBOC1 CAPSD_HBOC1] Capsid proteins self-assembles to form an icosahedral capsid with a T=1 symmetry, about 26 nm in diameter, and consisting of 60 copies of three size variants of the capsid proteins, VP1, and VP3, which differ by the presence of an N-terminal extension in the minor protein VP1 (Probable). The capsid has a channel at the 5-fold axis and there are densities extending the 5-fold axis into the interior of the capsid (PubMed:28331084). The capsid encapsulates the genomic ssDNA (Probable). Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region. The additional N-terminal region of isoform Minor capsid protein VP1, called VP1u, may serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus (By similarity).[UniProtKB:Q9PZT0]<ref>PMID:28331084</ref> <ref>PMID:28331084</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</SX> | </SX> | ||
[[Category: | [[Category: Human bocavirus 1]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Agbandje-McKenna | [[Category: Agbandje-McKenna M]] | ||
[[Category: Baker | [[Category: Baker T]] | ||
[[Category: Chipman | [[Category: Chipman P]] | ||
[[Category: Garrison | [[Category: Garrison J]] | ||
[[Category: Ilyas | [[Category: Ilyas M]] | ||
[[Category: Jansen | [[Category: Jansen M]] | ||
[[Category: Kailasan | [[Category: Kailasan S]] | ||
[[Category: Kandola | [[Category: Kandola K]] | ||
[[Category: McKenna | [[Category: McKenna R]] | ||
[[Category: Mietzsch | [[Category: Mietzsch M]] | ||
[[Category: Soderlund-Venermo | [[Category: Soderlund-Venermo M]] | ||
[[Category: Sousa | [[Category: Sousa D]] | ||
[[Category: Spear | [[Category: Spear J]] | ||
