5v5s: Difference between revisions

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<SX load='5v5s' size='340' side='right' viewer='molstar' caption='[[5v5s]], [[Resolution|resolution]] 6.50&Aring;' scene=''>
<SX load='5v5s' size='340' side='right' viewer='molstar' caption='[[5v5s]], [[Resolution|resolution]] 6.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5v5s]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V5S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V5S FirstGlance]. <br>
<table><tr><td colspan='2'>[[5v5s]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V5S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5V5S FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.5&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tolC, colE1-i, mtcB, mukA, refI, toc, weeA, b3035, JW5503 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895]), acrA, Z0578, ECs0516 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895]), acrB, acrE, b0462, JW0451 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v5s OCA], [http://pdbe.org/5v5s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v5s RCSB], [http://www.ebi.ac.uk/pdbsum/5v5s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v5s ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5v5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v5s OCA], [https://pdbe.org/5v5s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5v5s RCSB], [https://www.ebi.ac.uk/pdbsum/5v5s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5v5s ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TOLC_ECOLI TOLC_ECOLI]] Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells.<ref>PMID:6337123</ref> <ref>PMID:11274125</ref> <ref>PMID:15228545</ref> <ref>PMID:18955484</ref> <ref>PMID:23176499</ref> [[http://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI]] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref>  [[http://www.uniprot.org/uniprot/ACRA_ECO57 ACRA_ECO57]] AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together (By similarity).
[https://www.uniprot.org/uniprot/TOLC_ECOLI TOLC_ECOLI] Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells.<ref>PMID:6337123</ref> <ref>PMID:11274125</ref> <ref>PMID:15228545</ref> <ref>PMID:18955484</ref> <ref>PMID:23176499</ref>  
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</SX>
</SX>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Blaza, J N]]
[[Category: Blaza JN]]
[[Category: Chiu, W]]
[[Category: Chiu W]]
[[Category: Du, D]]
[[Category: Du D]]
[[Category: Hryc, C F]]
[[Category: Hryc CF]]
[[Category: Luisi, B F]]
[[Category: Luisi BF]]
[[Category: Schmid, M F]]
[[Category: Schmid MF]]
[[Category: Serysheva, I I]]
[[Category: Serysheva II]]
[[Category: Fan, G]]
[[Category: Fan G]]
[[Category: Wang, Z]]
[[Category: Wang Z]]
[[Category: Drug resistance]]
[[Category: Membrane protein]]
[[Category: Membrane transport]]
[[Category: Multi-drug efflux]]
[[Category: Rnd superfamily]]
Retrieved from "https://proteopedia.org/5v5s"