5x58: Difference between revisions

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<SX load='5x58' size='340' side='right' viewer='molstar' caption='[[5x58]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<SX load='5x58' size='340' side='right' viewer='molstar' caption='[[5x58]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5x58]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus_bj01 Sars coronavirus bj01]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X58 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X58 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5x58]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/SARS_coronavirus_BJ01 SARS coronavirus BJ01]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X58 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5X58 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x58 OCA], [http://pdbe.org/5x58 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x58 RCSB], [http://www.ebi.ac.uk/pdbsum/5x58 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x58 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5x58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x58 OCA], [https://pdbe.org/5x58 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5x58 RCSB], [https://www.ebi.ac.uk/pdbsum/5x58 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5x58 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SPIKE_SARS SPIKE_SARS] May down-regulate host tetherin (BST2) by lysosomal degradation, thereby counteracting its antiviral activity.<ref>PMID:31199522</ref>  Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 and CLEC4M/DC-SIGNR receptors and internalization of the virus into the endosomes of the host cell induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membrane fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:14670965</ref> <ref>PMID:15496474</ref>  Mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099]  Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]<ref>PMID:19321428</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5x58" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5x58" style="background-color:#fffaf0;"></div>
==See Also==
*[[Sandbox 3001|Sandbox 3001]]
*[[Spike protein 3D structures|Spike protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</SX>
</SX>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Sars coronavirus bj01]]
[[Category: SARS coronavirus BJ01]]
[[Category: Cao, D]]
[[Category: Cao D]]
[[Category: Gao, G F]]
[[Category: Gao GF]]
[[Category: Lu, G]]
[[Category: Lu G]]
[[Category: Ma, J]]
[[Category: Ma J]]
[[Category: Qi, J]]
[[Category: Qi J]]
[[Category: Shi, Y]]
[[Category: Shi Y]]
[[Category: Wang, Q]]
[[Category: Wang Q]]
[[Category: Wu, Y]]
[[Category: Wu Y]]
[[Category: Yan, J]]
[[Category: Yan J]]
[[Category: Yuan, Y]]
[[Category: Yuan Y]]
[[Category: Zhang, X]]
[[Category: Zhang X]]
[[Category: Zhang, Y]]
[[Category: Zhang Y]]
[[Category: Prefusion]]
[[Category: Sars-cov]]
[[Category: Single particle]]
[[Category: Spike glycoprotein]]
[[Category: Viral protein]]
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