6d6v: Difference between revisions

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<SX load='6d6v' size='340' side='right' viewer='molstar' caption='[[6d6v]], [[Resolution|resolution]] 4.80&Aring;' scene=''>
<SX load='6d6v' size='340' side='right' viewer='molstar' caption='[[6d6v]], [[Resolution|resolution]] 4.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6d6v]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D6V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D6V FirstGlance]. <br>
<table><tr><td colspan='2'>[[6d6v]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D6V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6D6V FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.8&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6d6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d6v OCA], [https://pdbe.org/6d6v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6d6v RCSB], [https://www.ebi.ac.uk/pdbsum/6d6v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6d6v ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d6v OCA], [http://pdbe.org/6d6v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d6v RCSB], [http://www.ebi.ac.uk/pdbsum/6d6v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d6v ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TERT_TETTH TERT_TETTH]] Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme (By similarity).  
[https://www.uniprot.org/uniprot/TERT_TETTS TERT_TETTS] Catalytic component of telomerase, an essential ribonucleoprotein enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER (PubMed:10944124, PubMed:15696174, PubMed:16462747, PubMed:17322903, PubMed:20713447). TERT is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme (PubMed:10944124, PubMed:15696174, PubMed:16462747, PubMed:17322903, PubMed:20713447).<ref>PMID:10944124</ref> <ref>PMID:15696174</ref> <ref>PMID:16462747</ref> <ref>PMID:17322903</ref> <ref>PMID:20713447</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Telomerase|Telomerase]]
*[[Telomerase 3D structures|Telomerase 3D structures]]
*[[Telomerase-associated protein|Telomerase-associated protein]]
*[[Telomerase-associated protein|Telomerase-associated protein]]
== References ==
== References ==
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</SX>
</SX>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: RNA-directed DNA polymerase]]
[[Category: Tetrahymena thermophila]]
[[Category: Tetrahymena thermophila]]
[[Category: Basu, R]]
[[Category: Basu R]]
[[Category: Chan, H]]
[[Category: Chan H]]
[[Category: Feigon, J]]
[[Category: Feigon J]]
[[Category: Jiang, J]]
[[Category: Jiang J]]
[[Category: Susac, L]]
[[Category: Susac L]]
[[Category: Wang, Y]]
[[Category: Wang Y]]
[[Category: Zhou, Z H]]
[[Category: Zhou ZH]]
[[Category: Replication]]
[[Category: Telomerase]]
[[Category: Telomere]]
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