6u5o: Difference between revisions

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<SX load='6u5o' size='340' side='right' viewer='molstar' caption='[[6u5o]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
<SX load='6u5o' size='340' side='right' viewer='molstar' caption='[[6u5o]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6u5o]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Hmpv Hmpv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U5O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U5O FirstGlance]. <br>
<table><tr><td colspan='2'>[[6u5o]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_metapneumovirus_CAN97-83 Human metapneumovirus CAN97-83]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U5O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6U5O FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u5o OCA], [http://pdbe.org/6u5o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u5o RCSB], [http://www.ebi.ac.uk/pdbsum/6u5o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u5o ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6u5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u5o OCA], [https://pdbe.org/6u5o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6u5o RCSB], [https://www.ebi.ac.uk/pdbsum/6u5o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6u5o ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/L_HMPVC L_HMPVC]] Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N(7)-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently the subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. The replicase mode is dependent on intracellular protein N concentration. In this mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals (By similarity). [[http://www.uniprot.org/uniprot/PHOSP_HMPVC PHOSP_HMPVC]] Acts as a cofactor that serves both to stabilize the protein L and to place the polymerase complex on the N:RNA template.  
[https://www.uniprot.org/uniprot/L_HMPVC L_HMPVC] Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N(7)-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently the subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. The replicase mode is dependent on intracellular protein N concentration. In this mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals (By similarity).
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</SX>
</SX>
[[Category: Hmpv]]
[[Category: Human metapneumovirus CAN97-83]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Fearns, R]]
[[Category: Fearns R]]
[[Category: Kalocsay, M]]
[[Category: Kalocsay M]]
[[Category: Lattmann, S]]
[[Category: Lattmann S]]
[[Category: Lescar, J]]
[[Category: Lescar J]]
[[Category: Pan, J]]
[[Category: Pan J]]
[[Category: Qian, X]]
[[Category: Qian X]]
[[Category: Sahili, A E]]
[[Category: Sahili AE]]
[[Category: Yeo, T H]]
[[Category: Yeo TH]]
[[Category: Human metapneumovirus]]
[[Category: Mononegavirale]]
[[Category: Phosphoprotein]]
[[Category: Pneumoviridae]]
[[Category: Polymerase]]
[[Category: Respiratory syncytial virus]]
[[Category: Rsv]]
[[Category: Viral protein]]
Retrieved from "https://proteopedia.org/6u5o"