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[[Image:1aqb.gif|left|200px]]
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{{STRUCTURE_1aqb|  PDB=1aqb  |  SCENE=  }}
'''RETINOL-BINDING PROTEIN (RBP) FROM PIG PLASMA'''


==RETINOL-BINDING PROTEIN (RBP) FROM PIG PLASMA==
<StructureSection load='1aqb' size='340' side='right'caption='[[1aqb]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1aqb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa_domesticus Sus scrofa domesticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AQB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=RTL:RETINOL'>RTL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aqb OCA], [https://pdbe.org/1aqb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aqb RCSB], [https://www.ebi.ac.uk/pdbsum/1aqb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aqb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RET4_PIG RET4_PIG] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aq/1aqb_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aqb ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of pig plasma retinol-binding protein (RBP) has been determined at 1.65 A resolution. The space group is P212121, with a = 45.81 (4), b = 53.14 (5), c = 72.97 (8) A and one protein molecule in the asymmetric unit. The structure has been solved using the molecular replacement method and refined with restrained least squares to an R factor of 0.1844 and an Rfree of 0.237 for 18 874 and 1001 independent reflections, respectively. The relatively high resolution structure of pig holoRBP has revealed some new structural details. Moreover, it has provided a description of the binding site for Cd2+, a metal ion which is required for protein crystallization. The hepta-coordination of the RBP-bound cadmium ion involves different residues of two symmetry-related RBP molecules, consistent with the participation of the cation in intermolecular interactions that in turn promote protein crystallization.


==Overview==
Structure of pig plasma retinol-binding protein at 1.65 A resolution.,Zanotti G, Panzalorto M, Marcato A, Malpeli G, Folli C, Berni R Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):1049-52. PMID:9757135<ref>PMID:9757135</ref>
The crystal structure of pig plasma retinol-binding protein (RBP) has been determined at 1.65 A resolution. The space group is P212121, with a = 45.81 (4), b = 53.14 (5), c = 72.97 (8) A and one protein molecule in the asymmetric unit. The structure has been solved using the molecular replacement method and refined with restrained least squares to an R factor of 0.1844 and an Rfree of 0.237 for 18 874 and 1001 independent reflections, respectively. The relatively high resolution structure of pig holoRBP has revealed some new structural details. Moreover, it has provided a description of the binding site for Cd2+, a metal ion which is required for protein crystallization. The hepta-coordination of the RBP-bound cadmium ion involves different residues of two symmetry-related RBP molecules, consistent with the participation of the cation in intermolecular interactions that in turn promote protein crystallization.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
1AQB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa_domestica Sus scrofa domestica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQB OCA].
</div>
<div class="pdbe-citations 1aqb" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
Structure of pig plasma retinol-binding protein at 1.65 A resolution., Zanotti G, Panzalorto M, Marcato A, Malpeli G, Folli C, Berni R, Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):1049-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9757135 9757135]
*[[Retinol-binding protein 3D structures|Retinol-binding protein 3D structures]]
[[Category: Single protein]]
== References ==
[[Category: Sus scrofa domestica]]
<references/>
[[Category: Berni, R.]]
__TOC__
[[Category: Folli, C.]]
</StructureSection>
[[Category: Malpeli, G.]]
[[Category: Large Structures]]
[[Category: Marcato, A.]]
[[Category: Sus scrofa domesticus]]
[[Category: Panzalorto, M.]]
[[Category: Berni R]]
[[Category: Zanotti, G.]]
[[Category: Folli C]]
[[Category: Cadmium ion]]
[[Category: Malpeli G]]
[[Category: Retinoid]]
[[Category: Marcato A]]
[[Category: Retinol transport]]
[[Category: Panzalorto M]]
[[Category: Vitamin some]]
[[Category: Zanotti G]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:34:51 2008''

Latest revision as of 23:47, 20 November 2024

RETINOL-BINDING PROTEIN (RBP) FROM PIG PLASMA

1aqb, resolution 1.65Å

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