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[[Image:1aqu.gif|left|200px]]
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{{STRUCTURE_1aqu|  PDB=1aqu  |  SCENE=  }}
'''ESTROGEN SULFOTRANSFERASE WITH BOUND INACTIVE COFACTOR PAP AND 17-BETA ESTRADIOL'''


==ESTROGEN SULFOTRANSFERASE WITH BOUND INACTIVE COFACTOR PAP AND 17-BETA ESTRADIOL==
<StructureSection load='1aqu' size='340' side='right'caption='[[1aqu]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1aqu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The August 2009 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Sulfotransferases''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2009_8 10.2210/rcsb_pdb/mom_2009_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AQU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=EST:ESTRADIOL'>EST</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aqu OCA], [https://pdbe.org/1aqu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aqu RCSB], [https://www.ebi.ac.uk/pdbsum/1aqu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aqu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ST1E1_MOUSE ST1E1_MOUSE] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aq/1aqu_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aqu ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The structure of estrogen sulphotransferase has been solved in the presence of inactive cofactor PAP and substrate 17 beta-estradiol. This structure reveals structural similarities between cytosolic sulphotransferases and nucleotide kinases.


==Overview==
Crystal structure of estrogen sulphotransferase.,Kakuta Y, Pedersen LG, Carter CW, Negishi M, Pedersen LC Nat Struct Biol. 1997 Nov;4(11):904-8. PMID:9360604<ref>PMID:9360604</ref>
The structure of estrogen sulphotransferase has been solved in the presence of inactive cofactor PAP and substrate 17 beta-estradiol. This structure reveals structural similarities between cytosolic sulphotransferases and nucleotide kinases.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
1AQU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQU OCA].
</div>
<div class="pdbe-citations 1aqu" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
Crystal structure of estrogen sulphotransferase., Kakuta Y, Pedersen LG, Carter CW, Negishi M, Pedersen LC, Nat Struct Biol. 1997 Nov;4(11):904-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9360604 9360604]
*[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]]
[[Category: Estrone sulfotransferase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Kakuta, Y.]]
[[Category: Sulfotransferases]]
[[Category: Negishi, M.]]
[[Category: Kakuta Y]]
[[Category: Pedersen, L C.]]
[[Category: Negishi M]]
[[Category: 17-beta estradiol]]
[[Category: Pedersen LC]]
[[Category: Estrogen]]
[[Category: Pap]]
[[Category: Steroid-binding]]
[[Category: Sulfonation]]
[[Category: Sulfotransferase]]
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:35:54 2008''

Latest revision as of 12:43, 26 July 2023

ESTROGEN SULFOTRANSFERASE WITH BOUND INACTIVE COFACTOR PAP AND 17-BETA ESTRADIOL

1aqu, resolution 1.60Å

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