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==LEM DOMAIN OF HUMAN INNER NUCLEAR MEMBRANE PROTEIN LAP2==
==LEM DOMAIN OF HUMAN INNER NUCLEAR MEMBRANE PROTEIN LAP2==
<StructureSection load='1h9f' size='340' side='right'caption='[[1h9f]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='1h9f' size='340' side='right'caption='[[1h9f]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1h9f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H9F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H9F FirstGlance]. <br>
<table><tr><td colspan='2'>[[1h9f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H9F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H9F FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1h9e|1h9e]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h9f OCA], [http://pdbe.org/1h9f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h9f RCSB], [http://www.ebi.ac.uk/pdbsum/1h9f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1h9f ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h9f OCA], [https://pdbe.org/1h9f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h9f RCSB], [https://www.ebi.ac.uk/pdbsum/1h9f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h9f ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/LAP2A_HUMAN LAP2A_HUMAN]] Defects in TMPO are the cause of cardiomyopathy dilated type 1T (CMD1T) [MIM:[http://omim.org/entry/613740 613740]]. A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:16247757</ref>
[https://www.uniprot.org/uniprot/LAP2A_HUMAN LAP2A_HUMAN] Defects in TMPO are the cause of cardiomyopathy dilated type 1T (CMD1T) [MIM:[https://omim.org/entry/613740 613740]. A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:16247757</ref>  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LAP2A_HUMAN LAP2A_HUMAN]] May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.  TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.  
[https://www.uniprot.org/uniprot/LAP2A_HUMAN LAP2A_HUMAN] May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.  TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Callebaut, I]]
[[Category: Callebaut I]]
[[Category: Courchay, K]]
[[Category: Courchay K]]
[[Category: Gilquin, B]]
[[Category: Gilquin B]]
[[Category: Laguri, C]]
[[Category: Laguri C]]
[[Category: Romi-Lebrun, R]]
[[Category: Romi-Lebrun R]]
[[Category: Wolff, N]]
[[Category: Wolff N]]
[[Category: Worman, H J]]
[[Category: Worman HJ]]
[[Category: Zinn-Justin, S]]
[[Category: Zinn-Justin S]]
[[Category: Emerin]]
[[Category: Inner nuclear membrane protein]]
[[Category: Lamina-associated polypeptide]]
[[Category: Lem domain]]
[[Category: Membrane protein]]
Retrieved from "https://proteopedia.org/1h9f"