Virion infectivity factor

spinqualitylabelsall models HIV-1 virion infectivity factor (deep sky blue) complex with human elongin-B (green) and elongin-C (pink) (PDB code 2ma9) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Virion infectivity factor (Vif) of HIV-1 is essential for efficient viral replication by binding to the a component of the innate immune system and triggering its polyubiquitination and rapid degradation thus preventing its entry into progeny virions. Interactions between HIV-1 virion infectivity factor and human elongin-B and elongin-C. For details see HIV and accessory proteins

3D Structures of virion infectivity factor

Updated on 19-March-2024

HIV and accessory proteins – HIVVif + cullin-5 + elongin-C + elongin-B + CBF-beta – HIV-1
8fvi, 8fvj – HIVVif + cullin-5 + elongin-C + elongin-B + CBF-beta – Cryo EM
2ma9, 3dcg – HIVVif + elongin-C + elongin-B
6nil – HIVVif + CBF-β + AF3 - Cryo EM
8cx0, 8cx1, 8cx2 – HIVVif + elongin-C + elongin-B + CBF-β + RNA – Cryo EM
8e40 – HIVVif + deoxycytidine deaminase + CBF-β + RNA – Cryo EM
6p59 – Vif + elongin-C + elongin-B + CBF-β – SIV-1
7upn – Vif + elongin-C + elongin-B + PPIase A – Visna-Maedi virus – Cryo EM

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