6y3i: Difference between revisions

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'''Unreleased structure'''


The entry 6y3i is ON HOLD  until Paper Publication
==NMR solution structure of the hazelnut allergen Cor a 1.0402==
<StructureSection load='6y3i' size='340' side='right'caption='[[6y3i]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6y3i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Corav Corav]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y3I FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y3i OCA], [https://pdbe.org/6y3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y3i RCSB], [https://www.ebi.ac.uk/pdbsum/6y3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y3i ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
A major proportion of allergic reactions to hazelnuts (Corylus avellana) are caused by immunologic cross-reactivity of IgE antibodies to pathogenesis-related class 10 (PR-10) proteins. Intriguingly, the four known isoforms of the hazelnut PR-10 allergen Cor a 1, denoted as Cor a 1.0401-Cor a 1.0404, share sequence identities exceeding 97% but possess different immunologic properties. In this work we describe the NMR solution structures of these proteins and provide an in-depth study of their biophysical properties. Despite sharing highly similar three-dimensional structures, the four isoforms exhibit remarkable differences regarding structural flexibility, hydrogen bonding and thermal stability. Our experimental data reveal an inverse relation between structural flexibility and IgE-binding in ELISA experiments, with the most flexible isoform having the lowest IgE-binding potential, while the isoform with the most rigid backbone scaffold displays the highest immunologic reactivity. These results point towards a significant entropic contribution to the process of antibody binding.


Authors: Fuehrer, S., Kamenik, A.S., Zeindl, R., Nothegger, B., Reider, N., Liedl, K.R., Tollinger, M.
Inverse relation between structural flexibility and IgE reactivity of Cor a 1 hazelnut allergens.,Fuhrer S, Kamenik AS, Zeindl R, Nothegger B, Hofer F, Reider N, Liedl KR, Tollinger M Sci Rep. 2021 Feb 18;11(1):4173. doi: 10.1038/s41598-021-83705-z. PMID:33603065<ref>PMID:33603065</ref>


Description: NMR solution structure of the hazelnut allergen Cor a 1.0402
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Zeindl, R]]
<div class="pdbe-citations 6y3i" style="background-color:#fffaf0;"></div>
[[Category: Kamenik, A.S]]
== References ==
[[Category: Liedl, K.R]]
<references/>
__TOC__
</StructureSection>
[[Category: Corav]]
[[Category: Large Structures]]
[[Category: Fuehrer, S]]
[[Category: Hofer, F]]
[[Category: Kamenik, A S]]
[[Category: Liedl, K R]]
[[Category: Nothegger, B]]
[[Category: Nothegger, B]]
[[Category: Reider, N]]
[[Category: Reider, N]]
[[Category: Fuehrer, S]]
[[Category: Tollinger, M]]
[[Category: Tollinger, M]]
[[Category: Zeindl, R]]
[[Category: Allergen]]
[[Category: Hazelnut allergen]]
[[Category: Pr-10 related protein]]
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