5cbk

Crystal structure of the strigolactone receptor ShHTL5 from Striga hermonthica

spinqualitylabelsall models 5cbk, resolution 2.46Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5cbk is a 1 chain structure with sequence from Striga hermonthica. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.462Å Ligands: CL, MG, PE3 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A0M5I297_STRHE Publication Abstract from PubMed Strigolactones are naturally occurring signaling molecules that affect plant development, fungi-plant interactions, and parasitic plant infestations. We characterized the function of 11 strigolactone receptors from the parasitic plant Striga hermonthica using chemical and structural biology. We found a clade of polyspecific receptors, including one that is sensitive to picomolar concentrations of strigolactone. A crystal structure of a highly sensitive strigolactone receptor from Striga revealed a larger binding pocket than that of the Arabidopsis receptor, which could explain the increased range of strigolactone sensitivity. Thus, the sensitivity of Striga to strigolactones from host plants is driven by receptor sensitivity. By expressing strigolactone receptors in Arabidopsis, we developed a bioassay that can be used to identify chemicals and crops with altered strigolactone levels. Structure-function analysis identifies highly sensitive strigolactone receptors in Striga.,Toh S, Holbrook-Smith D, Stogios PJ, Onopriyenko O, Lumba S, Tsuchiya Y, Savchenko A, McCourt P Science. 2015 Oct 9;350(6257):203-7. doi: 10.1126/science.aac9476. PMID:26450211 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Proteopedia Page Contributors and Editors (what is this?)

OCA