5cl2: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(One intermediate revision by the same user not shown)
Line 3: Line 3:
<StructureSection load='5cl2' size='340' side='right'caption='[[5cl2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='5cl2' size='340' side='right'caption='[[5cl2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5cl2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CL2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CL2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5cl2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CL2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">spo0M, ygaI, BSU08760 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224308 BACSU])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cl2 OCA], [http://pdbe.org/5cl2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cl2 RCSB], [http://www.ebi.ac.uk/pdbsum/5cl2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cl2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cl2 OCA], [https://pdbe.org/5cl2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cl2 RCSB], [https://www.ebi.ac.uk/pdbsum/5cl2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cl2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SP0M_BACSU SP0M_BACSU]] Controls the expression of spo0A and is required to pass the morphological stage 0 of sporulation.<ref>PMID:9795118</ref> 
[https://www.uniprot.org/uniprot/SP0M_BACSU SP0M_BACSU] Controls the expression of spo0A and is required to pass the morphological stage 0 of sporulation.<ref>PMID:9795118</ref>  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Spo0M is a sporulation-control protein that is thought to play an essential role in the early stage of endospore formation. While little is known about the functions of Spo0M, a recent phylogenetic study suggests that, based on its amino-acid sequence, Spo0M might belong to the arrestin clan. The crystal structure of the Spo0M protein was determined at a resolution of 2.3 A. Ten amino acids at the end of the N-terminus were removed to improve the thermal stability of the purified Spo0M protein and the crystal structure of Spo0M was determined by SAD. Spo0M has a well conserved N-terminal domain with an arrestin-like fold, which consists of a beta-strand sandwich structure. Surprisingly, the C-terminal domain of Spo0M, which has no structural homology to arrestin-clan proteins, bears significant structural similarity to the FP domain of the human PI31 protein. In addition, Spo0M harbours a potential polar-core structure connecting the N- and C-terminal domains with several salt bridges, as seen in the crystal structures of arrestin and VPS26. The structure reported here constitutes the first structural information on a bacterial protein that shares significant structural homology to members of the arrestin clan and the FP domain.
 
Structure of Spo0M, a sporulation-control protein from Bacillus subtilis.,Sonoda Y, Mizutani K, Mikami B Acta Crystallogr F Struct Biol Commun. 2015 Dec 1;71(Pt 12):1488-97. doi:, 10.1107/S2053230X15020919. Epub 2015 Nov 18. PMID:26625291<ref>PMID:26625291</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5cl2" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacsu]]
[[Category: Bacillus subtilis subsp. subtilis str. 168]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Mikami, B]]
[[Category: Mikami B]]
[[Category: Mizutani, K]]
[[Category: Mizutani K]]
[[Category: Sonoda, Y]]
[[Category: Sonoda Y]]
[[Category: Protein binding]]
[[Category: Spo0m]]
[[Category: Sporulation]]

Latest revision as of 09:08, 20 March 2024

Crystal structure of Spo0M, sporulation control protein, from Bacillus subtilis.

5cl2, resolution 2.30Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=5cl2&oldid=4105872"